发明申请
US20120005766A1 Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide
审中-公开
确定调节与破坏有关的表型的试剂的方法，编码PRO235多肽的基因
- 专利标题： Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide
- 专利标题（中）： 确定调节与破坏有关的表型的试剂的方法，编码PRO235多肽的基因
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申请号： US13205917申请日： 2011-08-09
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公开(公告)号： US20120005766A1公开(公告)日： 2012-01-05
- 发明人: Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
- 申请人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C12Q1/68 ; C40B30/04 ; C12Q1/02
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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