-
1.发明申请Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide 审中-公开确定调节与破坏有关的表型的试剂的方法，编码PRO235多肽的基因公开(公告)号：US20120005766A1
公开(公告)日：2012-01-05
申请号：US13205917
申请日：2011-08-09
申请人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
发明人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 循环异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
公开(公告)号：US20110182883A1
公开(公告)日：2011-07-28
申请号：US13040049
申请日：2011-03-03
申请人： Katherin E. Combs , Frederic de Sauvage , Liangfen Fan , Ellen Filvaroff , Allison Anne Byers Horner , Bryan Irving , Jagath Reddy Junutula , Erin Marie Massey , Dina Rebecca Mclain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Teresa Gail Townsend , Peter Vogel
发明人： Katherin E. Combs , Frederic de Sauvage , Liangfen Fan , Ellen Filvaroff , Allison Anne Byers Horner , Bryan Irving , Jagath Reddy Junutula , Erin Marie Massey , Dina Rebecca Mclain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Teresa Gail Townsend , Peter Vogel
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供了包含PRO218，PRO228，PRO271，PRO273，PRO295，PRO302，PRO305，PRO326，PRO386，PRO655，PRO162，PRO788，PRO792，PRO940，PRO941，PRO1004，PRO1012，PRO1016，PRO474，PRO5238中的中断的转基因小鼠 ，PRO1069，PRO1111，PRO1113，PRO1130，PRO1195，PRO1271，PRO1865，PRO1879，PRO3446，PRO3543，PRO4329，PRO4352，PRO5733，PRO9859，PRO9864，PRO9904，PRO9907，PRO10013，PRO90948，PRO28694，PRO16089，PRO19563，PRO19675，PRO20084，PRO21434 ，PRO50332，PRO38465或PRO346基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
公开(公告)号：US20090288176A1
公开(公告)日：2009-11-19
申请号：US11814025
申请日：2007-04-18
申请人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
发明人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
IPC分类号： G01N33/00 , A61K39/395 , C12N5/10 , C07K16/00 , A01K67/00
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K14/705 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO286，PRO706，PRO1800，PRO4354，PRO6029，PRO9739，PRO20044，PRO28631或PRO34128基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
公开(公告)号：US20090293137A1
公开(公告)日：2009-11-26
申请号：US11814413
申请日：2006-11-16
申请人： Katherin E. Combs , Frederic J. de Sauvage , Liangfen Fan , Ellen Filvaroff , Allison A. B. Horner , Bryan Irving , Jagath Reddy Juntula , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Heidi Philips , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Teresa G. Townsend , Peter Vogel
发明人： Katherin E. Combs , Frederic J. de Sauvage , Liangfen Fan , Ellen Filvaroff , Allison A. B. Horner , Bryan Irving , Jagath Reddy Juntula , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Heidi Philips , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Teresa G. Townsend , Peter Vogel
IPC分类号： A01K67/027 , C12N5/06 , C07K16/18 , C12Q1/02 , A61K39/395
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12N15/8509 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO 1016, PRO474, PRO5238, PRO1069, PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO218，PRO228，PRO271，PRO273，PRO295，PRO302，PRO305，PRO326，PRO386，PRO655，PRO162，PRO788，PRO792，PRO940，PRO941，PRO1004，PRO1012，PRO1016，PRO474， PRO5238，PRO1069，PRO1111，PRO1113，PRO1130，PRO1195，PRO1271，PRO1865，PRO1879，PRO3446，PRO3543，PRO4329，PRO4352，PRO5733，PRO9859，PRO9864，PRO9904，PRO9907，PRO10013，PRO90948，PRO28694，PRO16089，PRO19563，PRO19675，PRO20084， PRO21434，PRO50332，PRO38465或PRO346基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
5.发明申请Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same 审中-公开基因工程和表型小鼠和干细胞克隆生产它公开(公告)号：US20090113564A1
公开(公告)日：2009-04-30
申请号：US12057851
申请日：2008-03-28
申请人： Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
发明人： Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
IPC分类号： A01K67/027
CPC分类号： C12N15/873 , A01K2217/05 , C12N2799/027
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
-
公开(公告)号：US20100233153A1
公开(公告)日：2010-09-16
申请号：US12375662
申请日：2007-10-01
申请人： Mark Dominic Borromeo , Jaime-Jo Cunningham , Frederick Desauvage , Ellen Filvaroff , Mark Alan Klamer , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Peter Vogel
发明人： Mark Dominic Borromeo , Jaime-Jo Cunningham , Frederick Desauvage , Ellen Filvaroff , Mark Alan Klamer , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Peter Vogel
IPC分类号： A61K39/395 , C12N5/10 , C07K16/00 , A61K49/00 , A61P37/02 , A61P27/02 , A61P25/00 , A61P19/00 , A61P17/00 , A61P1/16 , A61P35/00 , A61P9/10 , A61P9/00 , A61P5/18 , C12Q1/02 , A01K67/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO1105, PRO1279 or PRO1783 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO1105，PRO1279或PRO1783基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
公开(公告)号：US20090196876A1
公开(公告)日：2009-08-06
申请号：US11577547
申请日：2005-10-18
申请人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
发明人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
IPC分类号： A61K39/395 , G01N33/00 , C12N5/10 , C07K16/18 , A61P27/00 , A61P25/00 , A61P25/18 , A61P25/22 , A61P37/00 , A61P13/12 , A61P3/00 , A61P19/00 , A61P9/00 , A61P35/00 , A61P41/00 , A61P3/10
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO194，PRO220，PRO241，PRO284，PRO331，PRO354，PRO355，PRO533，PRO541，PRO725，PRO937，PRO1014，PRO1120，PRO1182，PRO1325，PRO1382，PRO1410，PRO1555，PRO1556，PRO1760中的中断 ，PRO1787，PRO1868，PRO4326，PRO4332，PRO4346，PRO4400，PRO6003，PRO6094，PRO6244，PRO9820，PRO9828，PRO10274，PRO16090，PRO19644，PRO21340，PRO92165，PRO85143，PRO1124，PRO1026或PRO23370基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
8.发明申请Genetically engineered and phenotyped mice and stem cell clones for producing the same 审中-公开基因工程和表型小鼠和干细胞克隆用于生产相同的公开(公告)号：US20080189799A1
公开(公告)日：2008-08-07
申请号：US11978234
申请日：2007-10-26
申请人： Liangfen Fan , Glenn Friedrich , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
发明人： Liangfen Fan , Glenn Friedrich , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Peter Vogel , Brian Zambrowicz
IPC分类号： C12N15/11 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2267/03 , C07K14/705 , C07K14/70503 , C07K14/7151 , C07K14/775 , C07K14/8114 , C07K14/8121 , C12N9/1051 , C12N9/12 , C12N9/1205 , C12N2799/027 , C12N2800/60
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
-
公开(公告)号：US20120210450A1
公开(公告)日：2012-08-16
申请号：US13082706
申请日：2011-04-08
申请人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
发明人： Fred de Sauvage , Dorothy French , Lino Gonzalez , Asja Praetor , Weilan Ye , Katherin E. Combs , Zhiyong Ding , Allison Anne Byers Horner , Erin Marie Massey , Charles Montgomery , Laurie Jeanette Minze , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel
IPC分类号： G01N33/48
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO194，PRO220，PRO241，PRO284，PRO331，PRO354，PRO355，PRO533，PRO541，PRO725，PRO937，PRO1014，PRO1120，PRO1182，PRO1325，PRO1382，PRO1410，PRO1555，PRO1556，PRO1760中的中断 ，PRO1787，PRO1868，PRO4326，PRO4332，PRO4346，PRO4400，PRO6003，PRO6094，PRO6244，PRO9820，PRO9828，PRO10274，PRO16090，PRO19644，PRO21340，PRO92165，PRO85143，PRO1124，PRO1026或PRO23370基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
公开(公告)号：US20080311107A1
公开(公告)日：2008-12-18
申请号：US11814136
申请日：2007-02-09
申请人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel A. Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Trac Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
发明人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel A. Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Trac Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.054 秒)
