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1.发明申请Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide 审中-公开确定调节与破坏有关的表型的试剂的方法，编码PRO235多肽的基因公开(公告)号：US20120005766A1
公开(公告)日：2012-01-05
申请号：US13205917
申请日：2011-08-09
申请人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
发明人： Kristi Rae Bollinger , Katherin E. Combs , Jaime-Jo Cunningham , Ling Ling Culbertson , Frederic J. de Sauvage , Joel Edwards , Leslie Jane Green , Rosemary Girgis , Allison Anne Byers Horner , Dina Rebecca McLain , Charles Montgomery , Laurie Jeanette Minze , Bobby Joe Payne , Heidi Phillips , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Tracy Tzu-Ling Tang , Teresa Gail Townsend , Peter Vogel
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO188，PRO235，PRO266，PRO337，PRO361，PRO539，PRO698，PRO717，PRO846，PRO874，PRO98346，PRO1082，PRO1097，PRO1192，PRO1268，PRO1278，PRO1303，PRO1308，PRO1338，PRO1378中的中断 ，PRO1415，PRO1867，PRO1890，PRO3438，PRO19835，PRO36915，PRO36029，PRO4999，PRO5778，PRO5997，PRO6079，PRO6090，PRO7178，PRO21184，PRO7434，PRO9822，PRO9833，PRO9836，PRO9854，PRO9862，PRO10284，PRO37510，PRO35444，PRO20473，PRO21054 或PRO35246基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 循环异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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2.发明申请Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same 审中-公开基因工程和表型小鼠和干细胞克隆生产它公开(公告)号：US20090113564A1
公开(公告)日：2009-04-30
申请号：US12057851
申请日：2008-03-28
申请人： Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
发明人： Alejandro Abuin , Mark Dominic Borromeo , Katherin E. Combs , Ling Ling Culbertson , Zhi-Yong Ding , Joel Edwards , Liangfen Fan , Rosemary Girgis , Leslie Jane Green , Allison Anne Byers Horner , Erin Marie Massey , Dina Rebecca McLain , Laurie Jeanette Minze , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Brian Zambrowicz
IPC分类号： A01K67/027
CPC分类号： C12N15/873 , A01K2217/05 , C12N2799/027
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
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公开(公告)号：US20120030776A1
公开(公告)日：2012-02-02
申请号：US12910746
申请日：2010-10-22
申请人： Katherin E. Combs , Ling Ling Culbertson , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Rosemary Girgis , Allison Anne Byers Horner , Harald Junge , Jagath Reddy Junutula , Erin Marie Massey , Dina Rebecca McLain , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Ni Nancy Qian , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Weilan Ye
发明人： Katherin E. Combs , Ling Ling Culbertson , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Rosemary Girgis , Allison Anne Byers Horner , Harald Junge , Jagath Reddy Junutula , Erin Marie Massey , Dina Rebecca McLain , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Ni Nancy Qian , Carolina Rangel , Tracy Ellen Willis Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Weilan Ye
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20090288176A1
公开(公告)日：2009-11-19
申请号：US11814025
申请日：2007-04-18
申请人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
发明人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
IPC分类号： G01N33/00 , A61K39/395 , C12N5/10 , C07K16/00 , A01K67/00
CPC分类号： C12Q1/6883 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K14/705 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO286，PRO706，PRO1800，PRO4354，PRO6029，PRO9739，PRO20044，PRO28631或PRO34128基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20090313707A1
公开(公告)日：2009-12-17
申请号：US11814361
申请日：2006-05-18
申请人： Katherin E. Combs , Ling Ling Culbertson , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Rosemary Girgis , Allison A. B. Horner , Harald Junge , Jagath Reddy Junutula , Erin Marie Massey , Dina R. McLain , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Ni Nancy Qian , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Weilan Ye
发明人： Katherin E. Combs , Ling Ling Culbertson , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Rosemary Girgis , Allison A. B. Horner , Harald Junge , Jagath Reddy Junutula , Erin Marie Massey , Dina R. McLain , Charles Montgomery , Bobby Joe Payne , Heidi Phillips , Ni Nancy Qian , Carolina Rangel , Tracy E. W. Sevaux , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Peter Vogel , Weilan Ye
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括PRO69122，PRO204，PRO214，PRO222，PRO234，PRO265，PRO309，PRO332，PRO342，PRO356，PRO540，PRO618，PRO944，PRO994，PRO1079，PRO1110，PRO1122，PRO1138，PRO1190，PRO1272中的中断 ，PRO1286，PRO1295，PRO1309，PRO1316，PRO1383，PRO1384，PRO1431，PRO1434，PRO1475，PRO1481，PRO1568，PRO1573，PRO1599，PRO1604，PRO1605，PRO1693，PRO1753，PRO1755，PRO1777，PRO1788，PRO1864，PRO1925，PRO1926，PRO3566，PRO4330。 ，PRO4423，PRO36935，PRO4977，PRO4979，PRO4980，PRO4981，PRO5801，PRO5995，PRO6001，PRO6095，PRO6182，PRO7170，PRO7171，PRO7436，PRO9912，PRO9917，PRO37337，PRO37496，PRO19646，PRO21718，PRO19820，PRO21201，PRO20026，PRO20110，PRO23203 或PRO35250基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20110097330A1
公开(公告)日：2011-04-28
申请号：US11722967
申请日：2006-02-27
申请人： Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
发明人： Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
IPC分类号： A61K49/00 , C07K16/18 , A61K39/00 , A61P25/00 , A61P9/00 , A61P37/00 , A61P27/02 , A61P25/24 , A61P25/22 , A61P25/18 , A61P27/06 , A61P27/12 , A61P9/10 , A61P19/02 , A61P19/10 , C12Q1/68 , C12N5/071 , C12N5/0735 , C12Q1/02
CPC分类号： C07K14/47 , A01K2217/075 , A61K2039/505 , G01N2500/00
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO179，PRO181，PRO244，PRO247，PRO269，PRO293，PRO298，PRO339，PRO341，PRO347，PRO531，PRO537，PRO718，PRO773，PRO860，PRO871，PRO872，PRO813，PRO828，PRO1100中的中断 ，PRO1114，PRO115，PRO1126，PRO1133，PRO1154，PRO1185，PRO1194，PRO1287，PRO1291，PRO1293，PRO1310，PRO1312，PRO1335，PRO1339，PRO2155，PRO1356，PRO1385，PRO1412，PRO1487，PRO1758，PRO1779，PRO1785，PRO1889，PRO90318，PRO3434 ，PRO3579，PRO4322，PRO4343，PRO4347，PRO4403，PRO4976，PRO260，PRO6014，PRO6027，PRO6181，PRO6714，PRO9922，PRO7179，PRO7476，PRO9824，PRO19814，PRO19836，PRO20088，PRO70789，PRO50298，PRO51592，PRO1757，PRO4421，PRO9903，PRO1106 ，PRO1411，PRO1486，PRO1565，PRO4399或PRO4404基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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7.发明申请Genetically Engineered and Photyped Mice and Stem Cell Clones for Producing the Same 审中-公开基因工程和愚蠢的小鼠和干细胞克隆生产它公开(公告)号：US20090077680A1
公开(公告)日：2009-03-19
申请号：US12099465
申请日：2008-04-08
申请人： Alejandro Abuin , Joel Edwards , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Teresa Gail Townsend , Rosemary Girgis , Allison Anne Byers Horner , Peter Vogel , Brian Zambrowicz
发明人： Alejandro Abuin , Joel Edwards , Charles Montgomery , Bobby Joe Payne , Carolina Rangel , Arthur T. Sands , Zheng-Zheng Shi , Mary Jean Sparks , Teresa Gail Townsend , Rosemary Girgis , Allison Anne Byers Horner , Peter Vogel , Brian Zambrowicz
IPC分类号： A01K67/027 , C12N5/06 , C07K16/18
CPC分类号： A01K67/0276 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , C12N2840/44
摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.
摘要翻译： 本发明涉及基因工程小鼠，衍生自这些小鼠的细胞，以及对应于受工程突变影响的基因的多核苷酸和多肽。 本发明还涉及在本发明的小鼠中产生的抗体。 本发明还提供了使用本发明的小鼠，细胞，多核苷酸，多肽和抗体的方法。
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公开(公告)号：US20120174239A1
公开(公告)日：2012-07-05
申请号：US13317754
申请日：2011-10-27
申请人： Stephen Jay Anderson , Jane Brennan , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Nelda A. Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Jean Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
发明人： Stephen Jay Anderson , Jane Brennan , Frederic J. de Sauvage , Zhiyong Ding , Joel Edwards , Nelda A. Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Jean Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
IPC分类号： G01N21/64 , G01N23/083 , C40B30/04 , G01N33/53
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes.Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20070292438A1
公开(公告)日：2007-12-20
申请号：US10583466
申请日：2004-12-13
申请人： Stephen Anderson , Jane Brennan , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Nelda Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
发明人： Stephen Anderson , Jane Brennan , Frederic de Sauvage , Zhiyong Ding , Joel Edwards , Nelda Fikes , Wenhu Huang , Wenjun Ouyang , Carolina Rangel , Mamta Sangha , Zheng-Zheng Shi , Mary Sparks , Joseph Trackey , Melissa Vetter , Ching-Yun Wang , Jessica Woodings
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号：US20050005667A1
公开(公告)日：2005-01-13
申请号：US10616825
申请日：2003-07-10
IPC分类号： B21C37/16 , B21D19/08 , B21J5/08 , B60D1/06 , B60D1/14 , B60D1/52 , B62D21/09 , B62D25/20 , B21D41/04
摘要： A method for reinforcing an end of a metal tube, and a resultant receiver tube for a motor vehicle trailer hitch assembly, wherein the method and resultant tube does not require creating a fold in the metal tube to create a reinforcing lip. The integral lip is formed by the plastic deforming a length of the first end of the tube extending beyond the die wherein the deformable length is less than or equal to two times the wall thickness of the tube.
摘要翻译： 一种用于加强金属管的端部的方法，以及用于机动车辆拖车牵引组件的所得的接收管，其中所述方法和合成管不需要在金属管中产生折痕以产生加强唇缘。 整体式唇缘由塑料变形，使管的第一端的长度延伸超过模头，其中可变形长度小于或等于管的壁厚的两倍。
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