发明申请
- 专利标题： COMPOSITIONS AND METHODS OF TREATING TUMORS
- 专利标题（中）： 治疗肿瘤的组合物和方法
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申请号： US13080313申请日： 2011-04-05
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公开(公告)号： US20120014965A1公开(公告)日： 2012-01-19
- 发明人: Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
- 申请人： Mark I. Greene , Donald M. O'Rourke , Ramachandran Murali , Byeong Woo Park
- 专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 当前专利权人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- 主分类号： A61K38/02
- IPC分类号： A61K38/02 ; A61K31/711 ; A61P35/00 ; A61K39/395
摘要：
Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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