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公开(公告)号：US20120014965A1
公开(公告)日：2012-01-19
申请号：US13080313
申请日：2011-04-05
IPC分类号： A61K38/02 , A61K31/711 , A61P35/00 , A61K39/395
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
摘要翻译： 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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公开(公告)号：US20090010935A1
公开(公告)日：2009-01-08
申请号：US12114475
申请日：2008-05-02
IPC分类号： A61K39/395 , A61K31/7088 , A61P35/00
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
摘要翻译： 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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公开(公告)号：US20160289334A2
公开(公告)日：2016-10-06
申请号：US14729798
申请日：2015-06-03
IPC分类号： C07K16/32 , A61K45/06 , A61N5/10 , A61K39/395
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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公开(公告)号：US06417168B1
公开(公告)日：2002-07-09
申请号：US09111681
申请日：1998-07-08
IPC分类号： A01N4304
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
摘要翻译： 公开了治疗患有erbB蛋白介导的肿瘤的个体的方法。 公开了预防个体中erbB蛋白介导的肿瘤的方法。 所述方法包括向个体施用编码与erbB蛋白二聚化并且缺乏酪氨酸激酶活性的蛋白质的核酸分子。 公开了包含这种核酸分子（包括药物组合物）的组合物。
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公开(公告)号：US20150010551A1
公开(公告)日：2015-01-08
申请号：US14485525
申请日：2014-09-12
IPC分类号： C07K16/32 , A61K45/06 , A61N5/10 , A61K39/395
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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公开(公告)号：US20160083478A1
公开(公告)日：2016-03-24
申请号：US14729798
申请日：2015-06-03
IPC分类号： C07K16/32 , A61K45/06 , A61N5/10 , A61K39/395
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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公开(公告)号：US07625558B2
公开(公告)日：2009-12-01
申请号：US10100952
申请日：2002-03-19
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K38/1709 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/572 , A61N5/10 , C07K14/71 , C07K2317/24 , C07K2317/73 , A61K2300/00
摘要： Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise adminstering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
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8.发明授权公开(公告)号：US08993634B2
公开(公告)日：2015-03-31
申请号：US13700906
申请日：2011-05-26
IPC分类号： A61K31/17 , A61K31/15 , A61K31/165 , A61K45/06
CPC分类号： A61K31/15 , A61K31/165 , A61K31/17 , A61K45/06 , A61K2300/00
摘要： This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor.
摘要翻译： 本申请描述了用于抑制细胞增殖性疾病的药物组合物，试剂盒和方法，特别是特征在于包括Her2相关癌症的受体酪氨酸激酶（包括Her2相关癌症）的过度活跃和/或不适当活性特征的那些疾病，以及用于成像Her-2表达肿瘤的方法。
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公开(公告)号：US08445644B2
公开(公告)日：2013-05-21
申请号：US12787594
申请日：2010-05-26
申请人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
发明人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
IPC分类号： C07K16/00
CPC分类号： C07K14/71 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/48238 , A61K47/4833 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/62 , A61K47/646 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K51/10 , C07K7/06 , C07K7/08 , C07K14/7151 , C07K14/82
摘要： Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
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公开(公告)号：US20120245081A1
公开(公告)日：2012-09-27
申请号：US13210117
申请日：2011-08-15
IPC分类号： A61K38/08 , A61P31/18 , A61P27/02 , A61P1/16 , A61P13/12 , A61P29/00 , A61P37/06 , A61P19/02 , A61K38/12
CPC分类号： C07K14/70578 , A61K38/00
摘要： Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide mimetics. Exocyclic anti-Fas peptide mimetics were identified that block Fas receptor-ligand interactions, and modulate Fas biological activity both in vitro and in vivo. The mimetics are useful, e.g., for treating Fas-related pathologies.
摘要翻译： 开发了禁用Fas的外来肽模拟物。 构建了Fas受体 - 配体复合物的三维模型，并且结构上预测与结合配体相关的受体区域用于产生约束肽模拟物。 鉴定了外环抗Fas肽模拟物阻断Fas受体 - 配体相互作用，并在体外和体内调节Fas生物活性。 模拟物可用于例如治疗Fas相关病理学。
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