发明申请
US20120022141A1 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS
失效
用于抑制来自JC病毒的基因表达的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS
- 专利标题（中）： 用于抑制来自JC病毒的基因表达的组合物和方法
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申请号： US13252414申请日： 2011-10-04
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公开(公告)号： US20120022141A1公开(公告)日： 2012-01-26
- 发明人: Pamela Tan , Dinah Sah , Birgit Bramlage
- 申请人： Pamela Tan , Dinah Sah , Birgit Bramlage
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; C12N5/071 ; A61P31/20 ; C12N15/113 ; C12N5/10 ; C07H21/02 ; C12N15/63
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.