公开(公告)号：US08410261B2

公开(公告)日：2013-04-02

申请号：US13252414

申请日：2011-10-04

申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

IPC分类号： C07H21/02 ,  C12N15/11 ,  C12N5/00 ,  A61K9/127

CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

公开(公告)号：US20100227915A1

公开(公告)日：2010-09-09

申请号：US12720465

申请日：2010-03-09

申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

IPC分类号： A61K31/713 ,  C07H21/02 ,  C12N5/10 ,  C07H21/04 ,  C12N15/74 ,  A61P31/12

CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

公开(公告)号：US08058257B2

公开(公告)日：2011-11-15

申请号：US12720465

申请日：2010-03-09

申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

IPC分类号： A61K48/06 ,  C07H21/04 ,  C12N15/00

CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

公开(公告)号：US20070099860A1

公开(公告)日：2007-05-03

申请号：US11588674

申请日：2006-10-27

申请人： Dinah Sah ,  Philipp Hadwiger ,  Ingo Roehl ,  Birgit Bramlage ,  Pamela Tan ,  Hans-Peter Vornlocher ,  David Bumcrot

发明人： Dinah Sah ,  Philipp Hadwiger ,  Ingo Roehl ,  Birgit Bramlage ,  Pamela Tan ,  Hans-Peter Vornlocher ,  David Bumcrot

IPC分类号： A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the HD gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the HD gene, or a mutant form thereof, using the pharmaceutical composition; and methods for inhibiting the expression of the huntingtin gene in a cell.

摘要翻译： 本发明涉及用于抑制亨廷顿蛋白基因（HD基因）表达的双链核糖核酸（dsRNA），其包含长度小于25个核苷酸的核苷酸序列的反义链，并且至少与至少 HD基因的一部分。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 使用该药物组合物治疗由HD基因的表达引起的疾病或其突变形式的方法; 以及抑制细胞中亨廷顿蛋白基因表达的方法。

公开(公告)号：US20130158102A1

公开(公告)日：2013-06-20

申请号：US13779116

申请日：2013-02-27

申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

IPC分类号： C07H21/02

CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

公开(公告)号：US07691824B2

公开(公告)日：2010-04-06

申请号：US11741205

申请日：2007-04-27

申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

IPC分类号： A61K31/70 ,  C07H21/04 ,  C12N21/00 ,  C12N15/00 ,  C12N5/00

CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

公开(公告)号：US20120022141A1

公开(公告)日：2012-01-26

申请号：US13252414

申请日：2011-10-04

申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

IPC分类号： A61K31/713 ,  C12N5/071 ,  A61P31/20 ,  C12N15/113 ,  C12N5/10 ,  C07H21/02 ,  C12N15/63

CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

公开(公告)号：US20130184329A1

公开(公告)日：2013-07-18

申请号：US13659315

申请日：2012-10-24

申请人： Dinah Sah ,  Pamela Tan ,  Webster Cavenee ,  Frank Furnari ,  Maria del Mar Inda Perez ,  Rudy Bonavia

发明人： Dinah Sah ,  Pamela Tan ,  Webster Cavenee ,  Frank Furnari ,  Maria del Mar Inda Perez ,  Rudy Bonavia

IPC分类号： C12N15/113 ,  A61K31/713

CPC分类号： C12N15/1138 ,  A61K31/713 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.

摘要翻译： 本发明涉及靶向突变表皮生长因子受体（EGFR）的双链核糖核酸（dsRNA）以及使用dsRNA抑制突变EGFR表达的方法。

公开(公告)号：US20120022132A1

公开(公告)日：2012-01-26

申请号：US13061569

申请日：2009-09-02

申请人： Dinah Sah ,  Pamela Tan ,  Webster Cavenee ,  Frank Furnari ,  Maria del Mar Inda Perez ,  Rudy Bonavia

发明人： Dinah Sah ,  Pamela Tan ,  Webster Cavenee ,  Frank Furnari ,  Maria del Mar Inda Perez ,  Rudy Bonavia

IPC分类号： A61K31/713 ,  A61P35/00 ,  C12N5/071 ,  C07H21/02 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N15/1138 ,  A61K31/713 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR.

摘要翻译： 本发明涉及靶向突变表皮生长因子受体（EGFR）的双链核糖核酸（dsRNA）以及使用dsRNA抑制突变EGFR表达的方法。

公开(公告)号：US20070105806A1

公开(公告)日：2007-05-10

申请号：US11593099

申请日：2006-11-03

申请人： Dinah Sah ,  Maria Frank-Kamenetsky ,  Anke Geick ,  Philipp Hadwiger ,  Ingo Roehl ,  Pamela Tan ,  Hans-Peter Vornlocher

发明人： Dinah Sah ,  Maria Frank-Kamenetsky ,  Anke Geick ,  Philipp Hadwiger ,  Ingo Roehl ,  Pamela Tan ,  Hans-Peter Vornlocher

IPC分类号： A61K48/00 ,  C07J17/00 ,  C07H21/02 ,  C12N5/10 ,  C12N5/08 ,  C07F9/6533

CPC分类号： C12N15/1138 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3515 ,  C12N2310/3521

摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.

摘要翻译： 本发明涉及用于抑制Nav1.8基因（Nav1.8基因）表达的双链核糖核酸（dsRNA），其包含长度小于25个核苷酸的核苷酸序列的反义链，其基本上 与Nav1.8基因的至少一部分互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由使用该药物组合物的Nav1.8基因表达引起的疾病的方法; 以及抑制细胞中Nav1.8基因表达的方法。