发明申请
- 专利标题： BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
- 专利标题（中）： 用于交付活性剂的生物可降解脂肪
-
申请号： US13153200申请日： 2011-06-03
-
公开(公告)号： US20120027803A1公开(公告)日： 2012-02-02
- 发明人: Muthiah MANOHARAN , Martin Maier , Muthusamy Jayaraman , Shigeo Matsuda , Narayanannair K. Jayaprakash , Kallanthottathil G. Rajeev , Akin Akinc , Thomas A. Baillie
- 申请人： Muthiah MANOHARAN , Martin Maier , Muthusamy Jayaraman , Shigeo Matsuda , Narayanannair K. Jayaprakash , Kallanthottathil G. Rajeev , Akin Akinc , Thomas A. Baillie
- 申请人地址： US MA Cambridge
- 专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人： ALNYLAM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K47/44
- IPC分类号： A61K47/44 ; A61K31/713 ; A61P37/04 ; C12N5/071 ; C12N15/85 ; C07C229/30 ; A61K31/7088
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
公开/授权文献
- US09012498B2 Biodegradable lipids for the delivery of active agents 公开/授权日：2015-04-21
信息查询
IPC分类:
