Invention Application
- Patent Title: Fullerene Assisted Cell Penetrating Peptides
- Patent Title (中): 富勒烯辅助细胞穿透肽
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Application No.: US12294991Application Date: 2007-03-30
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Publication No.: US20120034162A1Publication Date: 2012-02-09
- Inventor: Andrew R. Barron , Jianzhong Yang , Jianhua Yang , Kuan Wang , Jonathan Driver
- Applicant: Andrew R. Barron , Jianzhong Yang , Jianhua Yang , Kuan Wang , Jonathan Driver
- Applicant Address: US TX Houston
- Assignee: William March Rice University
- Current Assignee: William March Rice University
- Current Assignee Address: US TX Houston
- International Application: PCT/US2007/065654 WO 20070330
- Main IPC: A61K51/08
- IPC: A61K51/08 ; C07K19/00 ; C12N5/071 ; A61K38/02 ; A61K38/14 ; A61K9/127 ; C07K2/00 ; C07K1/107 ; B82Y5/00
Abstract:
A composition and method is described for intracellular delivery of fullerene containing peptides. The composition and method involve fullerene-substituted phenylalanine as part of a peptide based delivery system. The presence of a fullerene-substituted amino acid in a peptide is found to alter the intracellular transport properties of the peptide.
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