发明申请
US20120035175A1 Novel salts as Anti-Inflammatory, Immunomodulatory and Anti-Proliferatory Agents
审中-公开
新型盐类作为抗炎,免疫调节和抗增殖剂
- 专利标题: Novel salts as Anti-Inflammatory, Immunomodulatory and Anti-Proliferatory Agents
- 专利标题(中): 新型盐类作为抗炎,免疫调节和抗增殖剂
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申请号: US13174900申请日: 2011-07-01
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公开(公告)号: US20120035175A1公开(公告)日: 2012-02-09
- 发明人: Aldo AMMENDOLA , Julia DIEDERICHS , Johann LEBAN , Daniel VITT
- 申请人: Aldo AMMENDOLA , Julia DIEDERICHS , Johann LEBAN , Daniel VITT
- 申请人地址: DE Martinsried
- 专利权人: 4SC AG
- 当前专利权人: 4SC AG
- 当前专利权人地址: DE Martinsried
- 主分类号: A61K31/196
- IPC分类号: A61K31/196 ; C07D213/64 ; A61K31/4418 ; C07D333/38 ; A61K31/381 ; C07D333/60 ; C07D307/30 ; A61K31/341 ; C07D265/30 ; A61K31/5375 ; C07D413/02 ; A61P29/00 ; A61P37/00 ; A61P35/00 ; A61P33/02 ; A61P31/12 ; A61P31/04 ; A61P27/02 ; A61P11/06 ; A61P37/06 ; A61P25/00 ; A61P19/04 ; A61P1/00 ; A61P17/06 ; C07C229/46
摘要:
The present invention relates to a salt selected from the group comprising the N-methyl-D-glucamine salt (NMG), the diethylamine salt (DEA) salt, the magnesium salt, the tromethamine salt, the choline salt, the L-arginine salt, the zinc salt, and the 4-(2-hydroxyethyl)morpholine (HEM) salt of compounds of the general formula (I) wherein X is selected from the group consisting of CH2, S, or O; D is O or S; R8 is hydrogen or alkyl; E is an optionally substituted phenylene group; Y is a monocyclic or bicyclic substituted or unsubstituted 6-9 membered ring system which may contain one or more heteroatoms selected from N or S and which contains at least one aromatic ring; n is 0 or 1; and q is 0 or 1; with the proviso that compounds wherein X═CH2, q=0, Y=unsubstituted phenyl and E=unsubstituted phenylene are excluded; or a hydrate thereof.
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