发明申请
US20120045451A1 Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
有权
Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白
- 专利标题: Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
- 专利标题(中): Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白
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申请号: US13245113申请日: 2011-09-26
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公开(公告)号: US20120045451A1公开(公告)日: 2012-02-23
- 发明人: Arnd Steuernagel , Karsten Eulenberg , Guenter Broenner , Thomas Ciossek , Bettina Rudolph , Dorothea Rudolph , Funmi Belgore , Stefan Jakel , Christoph Meyer
- 申请人: Arnd Steuernagel , Karsten Eulenberg , Guenter Broenner , Thomas Ciossek , Bettina Rudolph , Dorothea Rudolph , Funmi Belgore , Stefan Jakel , Christoph Meyer
- 申请人地址: DE Goettingen
- 专利权人: DeveloGen Aktiengesellschaft fuer Entwicklungsbiologische Forschung
- 当前专利权人: DeveloGen Aktiengesellschaft fuer Entwicklungsbiologische Forschung
- 当前专利权人地址: DE Goettingen
- 优先权: EP01125812.6 20011029; EP02011073.0 20020517
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; G01N33/573 ; C12Q1/48 ; A61K48/00 ; A61P3/04 ; C12Q1/68 ; A61K31/7088
摘要:
This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.