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    Methods for diagnosis and treatment of MDK1 signal transduction disorders
    2.
    发明授权
    Methods for diagnosis and treatment of MDK1 signal transduction disorders 失效

    公开(公告)号：US07034112B2

    公开(公告)日：2006-04-25

    申请号：US10073064

    申请日：2002-02-12

    Applicant: Thomas Ciossek ,  Axel Ullrich ,  Birgit Millauer

    Inventor： Thomas Ciossek ,  Axel Ullrich ,  Birgit Millauer

    IPC: C07K17/00

    CPC classification number: C07K16/40 ,  A61K38/00 ,  C07K14/71

    Abstract: The present invention relates to MDK1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing.Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a MDK1 receptor tyrosine kinase and a receptor for the kinase. The MDK1 receptor tyrosine kinase may be truncated and lack a kinase domain and may be selected from the group consisting of MDK1.T1, MDK1.T2, MDK1.Δ1 and MDK1.Δ2.

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    5.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 有权
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08828934B2

    公开(公告)日：2014-09-09

    申请号：US13245188

    申请日：2011-09-26

    Applicant: Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    Inventor： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC: A61K38/45 ,  C12N9/12 ,  A61K38/00

    CPC classification number: C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    Abstract: This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing a pancreatic malfunction, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing a pancreatic malfunction.

    Abstract translation: 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括识别具有升高的胰腺功能障碍或发展中的可能性的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定受试者是否具有Mnk2和/或Mnk1基因的遗传变体或其同源物，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述遗传变异体为 与胰腺功能障碍的发生概率相关。

    Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis
    6.
    发明授权
    Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis 失效
    蛋白二硫键异构酶和ABC转运蛋白同源蛋白参与能量稳态调节

    公开(公告)号：US07404952B2

    公开(公告)日：2008-07-29

    申请号：US11567079

    申请日：2006-12-05

    Applicant: Karsten Eulenberg ,  Gunter Bronner ,  Thomas Ciossek ,  Thomas Hader ,  Arnd Steuernagel

    Inventor： Karsten Eulenberg ,  Gunter Bronner ,  Thomas Ciossek ,  Thomas Hader ,  Arnd Steuernagel

    IPC: A61K38/71 ,  C12N9/10 ,  C07K1/00

    CPC classification number: A61K31/70 ,  A61K38/52 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/90 ,  C12Y503/04001

    Abstract: The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.

    Abstract translation: 本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病 胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病， 例如 生殖器官的癌症，睡眠呼吸暂停等。

    Protein Disulfide Isomerase and ABC Transporter Homologous Proteins Involved in the Regulation of Energy Homeostasis
    7.
    发明申请
    Protein Disulfide Isomerase and ABC Transporter Homologous Proteins Involved in the Regulation of Energy Homeostasis 失效
    蛋白二硫化物异构酶和ABC转运蛋白同源蛋白参与能量稳态调节

    公开(公告)号：US20070185048A1

    公开(公告)日：2007-08-09

    申请号：US11567079

    申请日：2006-12-05

    Applicant: Karsten Eulenberg ,  Gunter Bronner ,  Thomas Ciossek ,  Thomas Hader ,  Arnd Steuernagel

    Inventor： Karsten Eulenberg ,  Gunter Bronner ,  Thomas Ciossek ,  Thomas Hader ,  Arnd Steuernagel

    IPC: A61K48/00 ,  A01K67/027 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/90

    CPC classification number: A61K31/70 ,  A61K38/52 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/90 ,  C12Y503/04001

    Abstract: The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.

    Abstract translation: 本发明公开了三种调节甘油三酯的能量稳态和代谢的新型蛋白质，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及用于产生本发明的多肽和多核苷酸的载体，宿主细胞，抗体和重组方法。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节相关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症以及相关疾病 胰腺功能障碍（例如糖尿病），高血压，胰腺功能障碍，动脉硬化，冠状动脉疾病（CAD），冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石，癌症，糖尿病， 例如 生殖器官的癌症，睡眠呼吸暂停等。

    MDK1 polypeptides
    8.
    发明授权
    MDK1 polypeptides 失效
    MDK1多肽

    公开(公告)号：US06361984B1

    公开(公告)日：2002-03-26

    申请号：US08438265

    申请日：1995-05-09

    Applicant: Thomas Ciossek ,  Axel Ullrich ,  Birgit Millauer

    Inventor： Thomas Ciossek ,  Axel Ullrich ,  Birgit Millauer

    IPC: C12N900

    CPC classification number: C07K16/40 ,  A61K38/00 ,  C07K14/71

    Abstract: The present invention relates to MDK1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a MDK1 receptor tyrosine kinase and a receptor for the kinase. The MDK1 receptor tyrosine kinase may be truncated and lack a kinase domain and may be selected from the group consisting of MDK1.T1, MDK1.T2, MDK1.&Dgr;1 and MDK1.&Dgr;2.

    Abstract translation: 本发明涉及MDK1多肽，编码这种多肽的核酸，含有这种核酸的细胞，组织和动物，这种多肽的抗体，利用这些多肽的测定法，以及与上述所有方法有关的方法。治疗，诊断和 为特征为信号转导障碍异常的疾病或病症提供筛查。 信号转导途径涉及MDK1受体酪氨酸激酶与激酶受体之间的相互作用。 MDK1受体酪氨酸激酶可能被截短并缺少激酶结构域，并且可以选自MDK1.T1，MDK1.T2，MDK1.DELTA1和MDK1.DELTA2。

    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM
    9.
    发明申请
    Mnk KINASE HOMOLOGOUS PROTEINS INVOLVED IN THE REGULATION OF ENERGY HOMEOSTASIS AND ORGANELLE METABOLISM 有权
    Mnk激活能源家畜和有机物代谢调控中涉及的同种异体蛋白

    公开(公告)号：US20120045451A1

    公开(公告)日：2012-02-23

    申请号：US13245113

    申请日：2011-09-26

    Applicant: Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

    Inventor： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jakel ,  Christoph Meyer

    IPC: A61K39/395 ,  G01N33/573 ,  C12Q1/48 ,  A61K48/00 ,  A61P3/04 ,  C12Q1/68 ,  A61K31/7088

    CPC classification number: C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    Abstract: This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to using these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and activators, in the diagnosis and treatment of diseases and disorders related to body-weight regulation and thermogenesis. One aspect of the disclosure encompasses methods of identifying an animal or human having an elevated probability of having or developing obesity, the method comprising: (a) obtaining a biological sample from an animal or human subject; and (b) determining from the biological sample whether the animal or human subject has a genetic variant of an Mnk2 and/or Mnk1 gene or a homolog thereof, or an expression product of said Mnk2 and/or Mnk1 gene or homolog thereof, wherein said genetic variant is associated with an elevated probability of having or developing obesity.

    Abstract translation: 本发明涉及MAP激酶相互作用激酶（Mnk）基因家族的核酸序列及其编码的氨基酸序列的用途，以及使用Mnk核酸或多肽，特别是Mnk激酶抑制剂和激活剂的这些序列或效应物， 在与体重调节和产热相关的疾病和病症的诊断和治疗中。 本公开的一个方面包括鉴定具有升高的发生或发展肥胖的概率的动物或人的方法，所述方法包括：（a）从动物或人类受试者获得生物样品; 和（b）从生物样品中确定动物或人类受试者是否具有Mnk2和/或Mnk1基因或其同源物的遗传变体，或所述Mnk2和/或Mnk1基因的表达产物或其同源物，其中所述 遗传变异与增加或发展肥胖的可能性相关。

    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism
    10.
    发明授权
    Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism 失效
    参与调节能量稳态和细胞器代谢的Mnk激酶同源蛋白

    公开(公告)号：US08076098B2

    公开(公告)日：2011-12-13

    申请号：US12174301

    申请日：2008-07-16

    Applicant: Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    Inventor： Arnd Steuernagel ,  Karsten Eulenberg ,  Guenter Broenner ,  Thomas Ciossek ,  Bettina Rudolph ,  Dorothea Rudolph ,  Funmi Belgore ,  Stefan Jaekel ,  Christoph Meyer

    IPC: C12Q1/48

    CPC classification number: C12N9/1205 ,  A61K38/45 ,  Y10S514/909

    Abstract: The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

    Abstract translation: 本发明公开了调节能量稳态的Mnk同源蛋白质，甘油三酸酯的代谢和/或有助于细胞器的膜稳定性和/或功能，以及鉴定和编码本发明公开的蛋白质的多核苷酸。 本发明还涉及这些序列用于诊断，研究，预防和治疗与体重调节和产热有关的疾病和病症的用途，例如但不限于代谢性疾病如肥胖症，以及 相关疾病如进食障碍，恶病质，糖尿病，高血压，冠心病，高胆固醇血症，血脂异常，骨关节炎，胆结石和睡眠呼吸暂停，以及与ROS防御相关的疾病，如糖尿病，神经变性疾病和癌症，例如 生殖器官的癌症等。

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