发明申请
US20120045831A1 POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY
审中-公开
POLY（LACTIC-GLYCOLIC）酸交联丙烯酸酯（PLGA-ALN）用于干细胞分化和药物递送的短期控制释放系统
- 专利标题： POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY
- 专利标题（中）： POLY（LACTIC-GLYCOLIC）酸交联丙烯酸酯（PLGA-ALN）用于干细胞分化和药物递送的短期控制释放系统
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申请号： US12860377申请日： 2010-08-20
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公开(公告)号： US20120045831A1公开(公告)日： 2012-02-23
- 发明人: Mei-Ling Ho , Je-Ken Chang , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu
- 申请人： Mei-Ling Ho , Je-Ken Chang , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu
- 申请人地址： TW Kaohsiung City
- 专利权人： KAOHSIUNG MEDICAL UNIVERSITY
- 当前专利权人： KAOHSIUNG MEDICAL UNIVERSITY
- 当前专利权人地址： TW Kaohsiung City
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C08G63/06
摘要：
The present invention relates to a bisphosphonates and synthetic polymeric carriers to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising activation of the synthetic polymeric carriers and the cross linking reaction. The present invention further provides methods for enhancing stem cell differentiation into osteogenic lineage and chondrogenic lineage, which comprise culturing a population of stem cells in specific micro-environments.
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