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公开(公告)号：US20130171197A1
公开(公告)日：2013-07-04
申请号：US13338800
申请日：2011-12-28
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
CPC分类号： C12N5/0068 , A61K47/36 , C12N5/0667 , C12N2533/40 , C12N2533/80 , C12N2537/10
摘要： The present invention provides a hydrogel comprising a poly(N-isopropylacrylamide) cross-linked hyaluronic acid. The present invention also provides a method of synthesizing a hydrogel comprising poly(N-isopropylacrylamide) cross-linked hyaluronic acid, which comprises (a) synthesizing methacrylated hyaluronic acid; and (b) copolymerizing methacrylated hyaluronic acid with N-isopropylacrylamide.
摘要翻译： 本发明提供包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶。 本发明还提供一种合成包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶的方法，其包括（a）合成甲基丙烯酸酯化的透明质酸; 和（b）将甲基丙烯酸酯化的透明质酸与N-异丙基丙烯酰胺共聚。
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2.发明申请METHOD FOR CONTROLLED RELEASE OF PARATHYROID HORMONE FROM CROSS-LINKED HYALURONIC ACID HYDROGEL 有权从交联羟丙酸水合物中控制释放天冬酰胺的方法公开(公告)号：US20130183349A1
公开(公告)日：2013-07-18
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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3.发明申请POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY 审中-公开POLY（LACTIC-GLYCOLIC）酸交联丙烯酸酯（PLGA-ALN）用于干细胞分化和药物递送的短期控制释放系统公开(公告)号：US20120045831A1
公开(公告)日：2012-02-23
申请号：US12860377
申请日：2010-08-20
CPC分类号： C08G63/912 , C12N5/0667 , C12N2500/42 , C12N2501/999 , C12N2533/40 , C12N2537/10
摘要： The present invention relates to a bisphosphonates and synthetic polymeric carriers to form a sustained release system. The present invention also provides a method for preparing a sustained release system, comprising activation of the synthetic polymeric carriers and the cross linking reaction. The present invention further provides methods for enhancing stem cell differentiation into osteogenic lineage and chondrogenic lineage, which comprise culturing a population of stem cells in specific micro-environments.
摘要翻译： 本发明涉及形成持续释放系统的双膦酸盐和合成聚合物载体。 本发明还提供一种制备持续释放系统的方法，包括活化合成聚合物载体和交联反应。 本发明还提供了增强干细胞分化成成骨谱系和软骨形成谱系的方法，其包括在特定微环境中培养干细胞群体。
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4.发明授权Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel 有权从交联透明质酸水凝胶中控释甲状旁腺激素的方法公开(公告)号：US08883862B2
公开(公告)日：2014-11-11
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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5.发明申请POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY 审中-公开POLY（LACTIC-GLYCOLIC）酸交联丙烯酸酯（PLGA-ALN）用于干细胞分化和药物递送的短期控制释放系统公开(公告)号：US20120202064A1
公开(公告)日：2012-08-09
申请号：US13446827
申请日：2012-04-13
CPC分类号： C08G63/912 , C08J3/14 , C08J9/26 , C08J2201/0446 , C08J2367/04 , C12N5/0667 , C12N2500/42 , C12N2501/999 , C12N2533/40 , C12N2537/10 , Y10T428/2982
摘要： A short term controlled release composition which comprises poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN) is provided. The PLGA-ALN is constructed into 3D scaffolds (PLGA-ALN-3D) with pores size of 150-300 μm and average porosity of 85%, or microspheres (PLGA-ALN-M) with 50-100 μm in diameter. The released alendronate concentration is in the range of 5×10−7 M to 5×10−8 M.
摘要翻译： 提供了包含聚（乳酸 - 共 - 乙醇酸）交联阿仑膦酸盐（PLGA-ALN）的短期控释组合物。 将PLGA-ALN构建成孔径为150-300μm，平均孔隙率为85％的3D支架（PLGA-ALN-3D）或直径为50-100μm的微球（PLGA-ALN-M）。 释放的阿仑膦酸盐浓度在5×10-7M至5×10-8M的范围内。
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