发明申请
US20120053139A1 METHOD FOR IMPROVING PHARMACOKINETICS OF PROTEASE INHIBITORS AND PROTEASE INHIBITOR PRECURSORS
审中-公开
提高蛋白酶抑制剂和蛋白酶抑制剂前体药物动力学的方法
- 专利标题: METHOD FOR IMPROVING PHARMACOKINETICS OF PROTEASE INHIBITORS AND PROTEASE INHIBITOR PRECURSORS
- 专利标题(中): 提高蛋白酶抑制剂和蛋白酶抑制剂前体药物动力学的方法
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申请号: US13216743申请日: 2011-08-24
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公开(公告)号: US20120053139A1公开(公告)日: 2012-03-01
- 发明人: Jinzi Jason Wu , Brent Richard Stranix , Michael Ge , Guy Milot , Marco Petrella , Chandra J. Panchal
- 申请人: Jinzi Jason Wu , Brent Richard Stranix , Michael Ge , Guy Milot , Marco Petrella , Chandra J. Panchal
- 申请人地址: CA Montreal
- 专利权人: Ambrilia Biopharma Inc.
- 当前专利权人: Ambrilia Biopharma Inc.
- 当前专利权人地址: CA Montreal
- 主分类号: A61K31/661
- IPC分类号: A61K31/661 ; A61K31/197 ; A61K31/455 ; A61P31/18 ; A61K31/496 ; A61K31/4196 ; A61K31/415 ; A61K31/7048 ; A61K31/675 ; A61K31/427
摘要:
The present invention provides methods for improving the pharmacokinetics of protease inhibitors and protease inhibitor precursors and pharmaceutical composition comprising protease inhibitors or protease inhibitor precursors of formula I and a cytochrome P450 monooxigenase inhibitor; when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, alkyl-CO— or cycloalkyl-CO—, wherein X may be, for example, F, Cl, and Br, and wherein R2 and R3 are as defined herein.