A biopsy device having a stylet, an outer cannula, and a vacuum chamber is disclosed. The stylet includes a lumen with an open proximal end and a tissue receiving opening near a distal end thereof. The outer cannula is slidably disposed over the stylet and has an open distal end with a cutting edge formed thereon. The vacuum chamber is in communication with the lumen of the stylet. Actuation of the outer cannula causes a vacuum to be delivered to the tissue receiving opening through the lumen of the stylet before the outer cannula advances distally.