Memory reconfiguration during system run-time is described. In one example, a system includes a memory slot to carry a memory board and to connect the memory board to a memory controller for read and write operations, a logic device having a plurality of status registers to record the status of the memory slot and a plurality of control registers to control the operation of the memory slot, and a bus interface coupled through direct signal lines to the memory slot to communicate status and control signals with the memory slot and coupled through a serial bus to the logic device to communicate status and control signals with the logic device.