Invention Application
- Patent Title: siRNA MICROBICIDES FOR PREVENTING AND TREATING DISEASES
- Patent Title (中): 用于预防和治疗疾病的siRNA微生物剂
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Application No.: US13069589Application Date: 2011-03-23
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Publication No.: US20120087973A1Publication Date: 2012-04-12
- Inventor: Judy Lieberman , Deborah Palliser , David Knipe
- Applicant: Judy Lieberman , Deborah Palliser , David Knipe
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: President and Fellows of Harvard College,Immune Disease Institute, Inc.
- Current Assignee: President and Fellows of Harvard College,Immune Disease Institute, Inc.
- Current Assignee Address: US MA Cambridge US MA Boston
- Main IPC: A61K31/7105
- IPC: A61K31/7105 ; C12N5/071 ; A61P31/14 ; A61P31/12 ; A61P31/22 ; A61P31/20 ; C12N5/00 ; A61K9/127
Abstract:
The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally.
Information query
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