发明申请
- 专利标题: METHOD FOR ENHANCING EXPRESSION OF RECOMBINANT PROTEIN
- 专利标题(中): 用于增强重组蛋白表达的方法
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申请号: US13126355申请日: 2009-10-30
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公开(公告)号: US20120088819A1公开(公告)日: 2012-04-12
- 发明人: Makoto Inoue , Koichi Saeki , Jun You , Toshiaki Tabata , Hitoshi Iwasaki , Tsugumine Shu , Mamoru Hasegawa
- 申请人: Makoto Inoue , Koichi Saeki , Jun You , Toshiaki Tabata , Hitoshi Iwasaki , Tsugumine Shu , Mamoru Hasegawa
- 优先权: JP2008-282151 20081031
- 国际申请: PCT/JP2009/068682 WO 20091030
- 主分类号: A61K31/7088
- IPC分类号: A61K31/7088 ; C12N5/10 ; C12P21/00 ; C12N15/63
摘要:
The present invention provides methods for enhancing protein expression from an RNA viral vector and RNA viral vectors with enhanced protein expression capacity. The present inventors successfully increased the level of protein expression significantly by expressing the proteins fused with an AB5B protein from RNA viral vectors. Effective gene therapy, gene vaccination, monoclonal antibody preparation, or such can be achieved by using a gene transfer RNA viral vector of the present invention.
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