利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.029 秒)

    NON-REPLICATING PARAMYXOVIRIDAE VIRUS VECTOR
    4.
    发明申请
    NON-REPLICATING PARAMYXOVIRIDAE VIRUS VECTOR 审中-公开
    非替代寄生虫病毒载体

    公开(公告)号：US20100209974A1

    公开(公告)日：2010-08-19

    申请号：US12373684

    申请日：2007-07-03

    申请人： Jun You ,  Makoto Inoue ,  Mamoru Hasegawa

    发明人： Jun You ,  Makoto Inoue ,  Mamoru Hasegawa

    IPC分类号： C12N15/86 ,  C12N15/33 ,  C12N15/64

    CPC分类号： C12N15/86 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2820/00

    摘要： The present inventors succeeded in producing non-replicating SeV vectors whose genomic RNAs lack all genes for the NP, P, and L proteins, which are RNP-constituting proteins. The present inventors confirmed that the NP/P/L-deficient SeV vectors carrying a marker gene such as GFP provide high productivity, and high transfer and expression efficiencies of foreign genes (high MOI infection is essential for achieving high expression levels). By lacking the L gene or two or more of the NP, P, and L genes, the vectors of the present invention enable lowering the level of virus-derived proteins expressed in host cells, thereby reducing the immunogenicity upon in vivo administration.

    摘要翻译： 本发明人成功地生产了非复制型SeV载体，其基因组RNA缺乏作为构成RNP的蛋白质的NP，P和L蛋白的所有基因。 本发明人确认携带GFP等标记基因的NP / P / L-缺陷型SeV载体提供高生产率，外源基因的高转移和表达效率（高MOI感染对于获得高表达水平至关重要）。 通过缺乏L基因或两个以上的NP，P和L基因，本发明的载体能够降低在宿主细胞中表达的病毒衍生的蛋白质的水平，从而降低体内给药时的免疫原性。

    Minus strand rna virus vector carrying gene modified in high mutation region
    5.
    发明申请
    Minus strand rna virus vector carrying gene modified in high mutation region 审中-公开
    在高突变区域携带基因的减数链rna病毒载体

    公开(公告)号：US20070105208A1

    公开(公告)日：2007-05-10

    申请号：US10562408

    申请日：2004-06-30

    申请人： Jun You ,  Akihiro Iida ,  Mamoru Hasegawa

    发明人： Jun You ,  Akihiro Iida ,  Mamoru Hasegawa

    IPC分类号： C12N7/00 ,  C12N15/86

    CPC分类号： C12N15/86 ,  C12N2770/36143 ,  C12N2800/30

    摘要： The present invention provides minus-strand RNA viruses carrying a foreign gene that has a partial sequence corresponding to part of the minus-strand RNA virus E sequence and where the partial sequence has been altered. A foreign gene comprising such a partial E sequence is found to undergo mutations at high frequencies when the gene is carried by a minus-strand RNA virus. The generation of mutations in the gene carried by the minus-strand RNA virus can be prevented by altering the foreign gene sequence so as to not contain this sequence.

    摘要翻译： 本发明提供携带外源基因的负链RNA病毒，该外源基因具有对应于负链RNA病毒E序列的一部分的部分序列，并且其部分序列已被改变。 当基因由负链RNA病毒携带时，发现包含这种部分E序列的外源基因在高频下经历突变。 可以通过改变外源基因序列来防止由负链RNA病毒携带的基因中的突变的产生，从而不包含该序列。

    Pharmaceutical- or gene-carrier compositions with reduced hemagglutinating activity
    6.
    发明申请
    Pharmaceutical- or gene-carrier compositions with reduced hemagglutinating activity 审中-公开
    具有降低血凝活性的药物或基因 - 载体组合物

    公开(公告)号：US20050250718A1

    公开(公告)日：2005-11-10

    申请号：US10512906

    申请日：2003-04-30

    申请人： Hiroyuki Sakakibara ,  Hiroto Hara ,  Yasuji Ueda ,  Mamoru Hasegawa ,  Jun You

    发明人： Hiroyuki Sakakibara ,  Hiroto Hara ,  Yasuji Ueda ,  Mamoru Hasegawa ,  Jun You

    IPC分类号： A61K35/76 ,  A61K47/48 ,  A61K48/00 ,  C12N15/86

    CPC分类号： C12N15/86 ,  A61K35/76 ,  A61K47/60 ,  A61K47/6901 ,  A61K48/0008 ,  C12N2760/18832 ,  C12N2760/18845 ,  C12N2810/40

    摘要： The present invention provides pharmaceutical- or gene-carrier compositions with reduced hemagglutinating activity. By attaching a compound to a minus-strand RNA virus envelope protein having hemagglutinating activity, a pharmaceutical- or gene-carrier composition with lower hemagglutinating activity than a composition to which the compound has not been attached can be successfully constructed. For example, an embodiment of the present invention provides a viral vector whose erythrocyte agglutination activity and hemolytic activity are significantly lowered, and whose stability in blood is remarkably elevated. The pharmaceutical- or gene-carrier compositions provided in this invention can be preferably used for transferring pharmaceuticals or genes in vivo.

    摘要翻译： 本发明提供具有降低的血凝活性的药物或基因 - 载体组合物。 通过将化合物连接到具有血细胞凝集活性的负链RNA病毒包膜蛋白上，可以成功地构建具有比未附着化合物的组合物更低血细胞凝集活性的药物或基因 - 载体组合物。 例如，本发明的一个实施方案提供了一种病毒载体，其红细胞凝集活性和溶血活性显着降低，并且其在血液中的稳定性显着升高。 本发明提供的药物或基因 - 载体组合物可优选用于体内转移药物或基因。

    Compressor Sealing Arrangement
    7.
    发明申请
    Compressor Sealing Arrangement 有权
    压缩机密封安排

    公开(公告)号：US20090068048A1

    公开(公告)日：2009-03-12

    申请号：US12207051

    申请日：2008-09-09

    申请人： Robert C. Stover ,  Huaming Guo ,  Minghau Yan ,  Jun You ,  Yong Cao

    发明人： Robert C. Stover ,  Huaming Guo ,  Minghau Yan ,  Jun You ,  Yong Cao

    IPC分类号： F04C27/00 ,  F04C18/04

    CPC分类号： F04C18/0215 ,  F04C23/008 ,  F04C27/005

    摘要： A compressor may include a shell, first and second scroll members, a partition and a first annular seal. The partition may be fixed to the shell and may overly the first scroll member. The partition may include first and second sides having a second discharge opening passing therethrough and being in communication with the first discharge opening. The first side may include a protrusion extending toward the first scroll member and generally surrounding the second discharge opening. The first annular seal may sealingly engage the partition and may be displaceable radially inward to a position abutting the protrusion to limit a radially inward travel of the first annular seal.

    摘要翻译： 压缩机可以包括壳体，第一和第二涡旋构件，隔板和第一环形密封件。 分隔件可以固定到壳体并且可以过度地覆盖第一涡旋构件。 分隔件可以包括具有穿过其中并与第一排出口连通的第二排放口的第一和第二侧。 第一侧可以包括朝向第一涡旋构件延伸并且大致围绕第二排出口的突起。 第一环形密封件可以密封地接合隔板，并且可以径向向内移动到与突起抵接的位置，以限制第一环形密封件的径向向内行进。

    Application of OsSRO1c Gene in Controlling Rice Drought Resistance
    8.
    发明申请
    Application of OsSRO1c Gene in Controlling Rice Drought Resistance 审中-公开
    OsSRO1c基因在水稻耐旱性中的应用

    公开(公告)号：US20140208456A1

    公开(公告)日：2014-07-24

    申请号：US14009373

    申请日：2012-04-01

    申请人： Lizhong Xiong ,  Jun You

    发明人： Lizhong Xiong ,  Jun You

    IPC分类号： C12N15/82

    CPC分类号： C12N15/8273 ,  C07K14/415

    摘要： Rice OsSRO1C gene conferring enhanced drought resistance of a plant is provided, wherein the said gene encodes an amino acid sequences as set forth in SEQ ID NO: 2. DNA constructs, transgenic plants or cells comprising the OsSRO1C gene and the uses of the OsSRO1C gene in improving though resistance of a plant are also provided. The OsSRO1C gene controlling rice drought resistance is cloned by screening a rice T-DNA insertion mutant database and determination of expression level and identification of drought stress phenotype, which shows that the mutant is co-segregated with the drought susceptible phenotype.

    摘要翻译： 提供赋予植物抗旱性的水稻OsSRO1C基因，其中所述基因编码如SEQ ID NO：2所示的氨基酸序列.DNA构建体，转基因植物或包含OsSRO1C基因的细胞和OsSRO1C基因的用途 在提高植物抗药性方面也有提高。 通过筛选水稻T-DNA插入突变体数据库，测定表达水平和鉴定干旱胁迫表型，克隆了耐旱稻田OsSRO1C基因，表明突变体与干旱易感基因表型共分离。

    Continuous microwave freeze-drying device
    9.
    发明授权
    Continuous microwave freeze-drying device 有权
    连续微波冷冻干燥装置

    公开(公告)号：US09568243B2

    公开(公告)日：2017-02-14

    申请号：US13990767

    申请日：2011-06-15

    申请人： Chaohui Liu ,  Chuan Zhou ,  Yi Liu ,  Qi Kang ,  Jun You ,  Kun Zhou

    发明人： Chaohui Liu ,  Chuan Zhou ,  Yi Liu ,  Qi Kang ,  Jun You ,  Kun Zhou

    IPC分类号： F26B3/347 ,  F26B5/06 ,  F26B5/04

    CPC分类号： F26B3/347 ,  F26B5/042 ,  F26B5/048 ,  F26B5/06

    摘要： A continuous microwave freeze-drying device comprises a vacuum water-trapping system (1), a microwave shield plate (2), a microwave bin (6) and a freeze-drying bin (5) located in the microwave bin (6), wherein the freeze-drying bin (5) comprises an upper bin opening, a left bin wall, a right bin wall and a bottom bin wall, and the left, right and bottom bin walls are all made from nonmetal wave transmitting materials, such as polyfluortetraethylene, polyethylene, polypropylene or quartz glass. The device solves the technical problem of freeze-drying failure caused by glow discharge of microwave under freeze-drying environment.

    摘要翻译： 连续的微波冷冻干燥装置包括位于微波炉（6）中的真空吸水系统（1），微波屏蔽板（2），微波炉（6）和冷冻干燥箱（5） 其特征在于，所述冷冻干燥箱（5）包括上部箱体开口，左侧箱壁，右侧箱壁和底部箱体壁，左侧和右侧箱体壁全部由非金属波浪传输材料制成，例如 聚四氟乙烯，聚乙烯，聚丙烯或石英玻璃。 该装置解决了冷冻干燥环境下微波辉光放电引起的冷冻干燥故障的技术问题。

    Compressor with retaining mechanism
    10.
    发明授权
    Compressor with retaining mechanism 有权
    带保持机构的压缩机

    公开(公告)号：US08356987B2

    公开(公告)日：2013-01-22

    申请号：US12207072

    申请日：2008-09-09

    申请人： Huaming Guo ,  Jun You ,  Yong Cao

    发明人： Huaming Guo ,  Jun You ,  Yong Cao

    IPC分类号： F04C18/00 ,  F04C2/00

    CPC分类号： F04C23/008 ,  F01C21/10 ,  F04C18/0215 ,  F04C2230/603 ,  F04C2240/30 ,  F16C2360/42 ,  Y10T29/49229 ,  Y10T29/49236 ,  Y10T29/4924 ,  Y10T137/7857 ,  Y10T137/7891 ,  Y10T137/7892 ,  Y10T137/85978

    摘要： A compressor may include a shell and a housing fixed within the shell. A compression mechanism may be supported by the housing and may include an orbiting scroll member and a non-orbiting scroll member that are meshingly engaged to form a series of compression pockets. A retaining assembly may include an axial retention member and a rotational retention member, each of which is engaged with the non-orbiting scroll member to limit axial translation and rotation of the non-orbiting scroll member relative to the housing.

    摘要翻译： 压缩机可以包括壳体和固定在壳体内的壳体。 压缩机构可以由壳体支撑，并且可以包括绕动涡旋构件和非绕动涡旋构件，其啮合地接合以形成一系列压缩腔。 保持组件可以包括轴向保持构件和旋转保持构件，每个构件与非绕动涡旋构件接合以限制非绕动涡旋构件相对于壳体的轴向平移和旋转。