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公开(公告)号：US20120088819A1
公开(公告)日：2012-04-12
申请号：US13126355
申请日：2009-10-30
申请人： Makoto Inoue , Koichi Saeki , Jun You , Toshiaki Tabata , Hitoshi Iwasaki , Tsugumine Shu , Mamoru Hasegawa
发明人： Makoto Inoue , Koichi Saeki , Jun You , Toshiaki Tabata , Hitoshi Iwasaki , Tsugumine Shu , Mamoru Hasegawa
IPC分类号： A61K31/7088 , C12N5/10 , C12P21/00 , C12N15/63
CPC分类号： C12N15/67 , A61K2039/53 , C07K2319/55 , C12N15/86 , C12N2760/18843
摘要： The present invention provides methods for enhancing protein expression from an RNA viral vector and RNA viral vectors with enhanced protein expression capacity. The present inventors successfully increased the level of protein expression significantly by expressing the proteins fused with an AB5B protein from RNA viral vectors. Effective gene therapy, gene vaccination, monoclonal antibody preparation, or such can be achieved by using a gene transfer RNA viral vector of the present invention.
摘要翻译： 本发明提供了从具有增强的蛋白质表达能力的RNA病毒载体和RNA病毒载体增强蛋白质表达的方法。 通过从RNA病毒载体表达与AB5B蛋白质融合的蛋白质，本发明人通过显着地成功地提高了蛋白质表达水平。 有效的基因治疗，基因疫苗接种，单克隆抗体制备等可以通过使用本发明的基因转移RNA病毒载体来实现。
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公开(公告)号：US20120087940A1
公开(公告)日：2012-04-12
申请号：US13126293
申请日：2009-10-30
申请人： Makoto Inoue , Koichi Saeki , Jun You , Toshiaki Tabata , Hitoshi Iwasaki , Tsugumine Shu , Mamoru Hasegawa
发明人： Makoto Inoue , Koichi Saeki , Jun You , Toshiaki Tabata , Hitoshi Iwasaki , Tsugumine Shu , Mamoru Hasegawa
IPC分类号： A61K31/7105 , A61P25/28 , C12N15/86 , A61K39/00
CPC分类号： A61K39/0007 , A61K38/00 , A61K2039/53 , A61K2039/545 , C07K14/4711 , C07K2319/55 , C12N2760/18843 , C12N2799/021 , C12N2799/04
摘要： The present invention provides methods for efficiently inducing anti-Aβ antibody and methods for preventing and treating Alzheimer's disease. The present inventors successfully induced anti-Aβ antibody in a highly efficient manner by administering an RNA viral vector that expresses a fusion protein between an AB5 toxin B subunit and an Aβ antigen peptide. Administration of the vector resulted in a significant increase of anti-Aβ antibody in plasma, and decrease in the Aβ level in brain tissues and decrease in the anti-Aβ antibody-positive area. The present invention enables more efficient vaccine gene therapy for preventing and treating Alzheimer's disease.
摘要翻译： 本发明提供了有效诱导抗Aβ的方法。 抗体和预防和治疗阿尔茨海默病的方法。 本发明人成功地诱导了抗A＆Bgr; 抗体，通过施用在AB5毒素B亚基和A＆bgr之间表达融合蛋白的RNA病毒载体以高效的方式; 抗原肽。 载体的施用导致抗A和Bgr的显着增加; 血浆中的抗体，A和Bgr的减少; 脑组织中的水平和抗A和Bgr的降低; 抗体阳性区。 本发明使得能够更有效地预防和治疗阿尔茨海默病的疫苗基因治疗。
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公开(公告)号：US20090246170A1
公开(公告)日：2009-10-01
申请号：US12302927
申请日：2007-05-31
申请人： Makoto Inoue , Yumiko Tokusumi , Hitoshi Iwasaki , Hiroto Hara , Toshiaki Tabata , Mamoru Hasegawa
发明人： Makoto Inoue , Yumiko Tokusumi , Hitoshi Iwasaki , Hiroto Hara , Toshiaki Tabata , Mamoru Hasegawa
IPC分类号： A61K38/20 , A61K31/7088 , A61K38/19 , A61K38/02 , A61P25/28
CPC分类号： A61K35/76 , A61K38/2026 , A61K38/2066 , A61K38/2086 , A61K48/00 , C07K14/5428 , C12N15/86 , C12N2760/18843 , A61K2300/00
摘要： The present invention provides novel therapeutic methods and agents for treating Alzheimer's disease. Specifically, the present invention relates to anti-inflammatory cytokines, anti-inflammatory cytokine genes, negative-strand RNA viral vectors carrying an anti-inflammatory cytokine gene, which are used for treating Alzheimer's disease or developing therapeutic agents for Alzheimer's disease. The present invention also provides pharmaceutical compositions for treating or preventing Alzheimer's disease, which comprise the cytokines or vectors. The present invention further provides methods for treating Alzheimer's disease, which comprise the step of administering an anti-inflammatory cytokine, or a vector such as a negative-strand RNA viral vector carrying an anti-inflammatory cytokine gene. The present invention enables novel gene therapies for Alzheimer's disease.
摘要翻译： 本发明提供治疗阿尔茨海默氏病的新型治疗方法和药剂。 具体而言，本发明涉及抗炎细胞因子，抗炎细胞因子基因，携带抗炎细胞因子基因的负链RNA病毒载体，其用于治疗阿尔茨海默病或开发阿尔茨海默氏病的治疗剂。 本发明还提供了用于治疗或预防阿尔茨海默病的药物组合物，其包含细胞因子或载体。 本发明还提供了治疗阿尔茨海默病的方法，其包括施用抗炎细胞因子的步骤，或携带抗炎细胞因子基因的载体如负链RNA病毒载体。 本发明使得能够进行阿尔茨海默病的新基因治疗。
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4.发明申请GENE TRANSFER INTO AIRWAY EPITHELIAL STEM CELL BY USING LENTIVIRAL VECTOR PSEUDOTYPED WITH RNA VIRUS OR DNA VIRUS SPIKE PROTEIN 审中-公开通过使用用RNA病毒或DNA病毒SPIKE蛋白质刺激的宿主细胞将基因转移到空中上皮细胞中公开(公告)号：US20090162320A1
公开(公告)日：2009-06-25
申请号：US12091646
申请日：2006-10-27
CPC分类号： C12N15/86 , A61K9/0043 , A61K38/162 , A61K38/1709 , A61K38/177 , A61K48/00 , C07K14/4712 , C12N5/0688 , C12N7/00 , C12N2510/00 , C12N2740/15033 , C12N2740/15043 , C12N2740/15045 , C12N2810/6072 , C12N2810/609
摘要： The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.
摘要翻译： 本发明人成功地将基因引入气道上皮组织的干细胞，其中使用以F和HN为假型的猿免疫缺陷病毒载体，其是仙台病毒的包膜糖蛋白。 使用本发明的载体将基因转移到气道上皮组织干细胞中可用于遗传呼吸系统疾病如囊性纤维化的基因治疗。 此外，可以选择诸如肺的呼吸器官作为用于提供由于遗传疾病而缺陷的蛋白质的生产组织。
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5.发明授权Spin torque oscillator, magnetic recording head, magnetic head assembly and magnetic recording apparatus 失效旋转扭矩振荡器，磁记录头，磁头组件和磁记录装置公开(公告)号：US08467148B2
公开(公告)日：2013-06-18
申请号：US12588176
申请日：2009-10-06
IPC分类号： G11B5/127
CPC分类号： G11B5/3146 , G11B5/314 , G11B2005/0005 , G11B2005/0024 , G11C11/161 , G11C11/1673 , G11C11/1675 , H01L43/08 , H03B15/006
摘要： A spin torque oscillator includes an amorphous soft magnetic layer, a nonmagnetic layer and a hard magnetic layer. The nonmagnetic layer with a close-packed crystal structure is provided on the amorphous soft magnetic layer. The hard magnetic layer with a close-packed crystal structure and perpendicular magnetic anisotropy is provided on the nonmagnetic layer.
摘要翻译： 自旋转矩振荡器包括非晶软磁层，非磁性层和硬磁层。 在非晶软磁层上提供具有紧密结晶结构的非磁性层。 在非磁性层上提供具有紧密堆积晶体结构和垂直磁各向异性的硬磁性层。
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公开(公告)号：US08446691B2
公开(公告)日：2013-05-21
申请号：US13459610
申请日：2012-04-30
申请人： Masayuki Takagishi , Hitoshi Iwasaki , Kenichiro Yamada , Katsuhiko Koui , Tomomi Funayama , Masahiro Takashita , Mariko Kitazaki , Soichi Oikawa
发明人： Masayuki Takagishi , Hitoshi Iwasaki , Kenichiro Yamada , Katsuhiko Koui , Tomomi Funayama , Masahiro Takashita , Mariko Kitazaki , Soichi Oikawa
IPC分类号： G11B5/127
CPC分类号： G11B5/3146 , G11B5/02 , G11B5/1278 , G11B5/65 , G11B2005/0005 , G11B2005/0024 , H01F10/123 , H01L43/08
摘要： According to one embodiment, a magnetic recording device includes a magnetic recording head and a magnetic recording medium. The magnetic recording head includes a main magnetic pole, a shield and a stacked structure. The main magnetic pole has a medium facing surface and a main magnetic pole side surface. The shield has a shield side surface. The stacked structure is provided between the main magnetic pole and shield, and includes first and second magnetic layers, and an intermediate layer. The magnetic recording medium includes a backing layer and a magnetic recording layer. A distance between an end portion of the medium facing surface on a side of the stacked structure and the backing layer is twice or more of a distance between the main magnetic pole side surface and the shield side surface.
摘要翻译： 根据一个实施例，磁记录装置包括磁记录头和磁记录介质。 磁记录头包括主磁极，屏蔽和堆叠结构。 主磁极具有中等面向表面和主磁极侧表面。 屏蔽有屏蔽侧面。 堆叠结构设置在主磁极和屏蔽之间，并且包括第一和第二磁性层以及中间层。 磁记录介质包括背衬层和磁记录层。 层叠结构一侧的介质相对表面的端部与背衬层之间的距离是主磁极侧表面和屏蔽侧表面之间的距离的两倍或更多。
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公开(公告)号：US08400734B2
公开(公告)日：2013-03-19
申请号：US13214012
申请日：2011-08-19
申请人： Kenichiro Yamada , Hitoshi Iwasaki , Junichi Akiyama , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu , Shuichi Murakami , Tadashi Kai
发明人： Kenichiro Yamada , Hitoshi Iwasaki , Junichi Akiyama , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu , Shuichi Murakami , Tadashi Kai
CPC分类号： G01S19/36 , G01S19/30 , Y10T428/1186
摘要： An example magnetic recording head includes: a main magnetic pole; a laminated body; and a pair of electrodes. The laminated body includes a first magnetic layer having a coercivity lower than magnetic field applied by the main magnetic pole, a second magnetic layer having a coercivity lower than the magnetic field applied by the main magnetic pole, and an intermediate layer provided between the first magnetic layer and the second magnetic layer. The pair of electrodes is operable to pass a current through the laminated body.
摘要翻译： 一个示例磁记录头包括：主磁极; 层压体; 和一对电极。 层叠体包括具有比由主磁极施加的磁场低的矫顽力的第一磁性层，具有低于由主磁极施加的磁场的矫顽力的第二磁性层，以及设置在第一磁性体之间的中间层 层和第二磁性层。 该对电极可操作以使电流通过层压体。
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公开(公告)号：US08320079B2
公开(公告)日：2012-11-27
申请号：US12457657
申请日：2009-06-17
申请人： Hitoshi Iwasaki , Kenichiro Yamada , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu , Soichi Oikawa , Katsuhiko Koui
发明人： Hitoshi Iwasaki , Kenichiro Yamada , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu , Soichi Oikawa , Katsuhiko Koui
CPC分类号： B82Y10/00 , B82Y25/00 , G11B5/3906 , G11B2005/0005 , G11B2005/3996
摘要： It is made possible to reduce the write magnetic field generated from the main magnetic pole toward the spin torque oscillator, so as to reduce the variation in the oscillation characteristics of the spin torque oscillator, and reduce the current required for oscillation. The magnetic head assembly includes: a recording magnetic pole; a spin torque oscillator that has first and second magnetic layers, and an intermediate layer interposed between the first and second magnetic layers, the spin torque oscillator generating a high-frequency magnetic field by applying a current between the first and second magnetic layers; and a third magnetic layer that is placed adjacent to at least part of a side face of the second magnetic layer.
摘要翻译： 可以将从主磁极产生的写入磁场减小到自旋转矩振荡器，从而减小自旋转矩振荡器的振荡特性的变化，并且降低振荡所需的电流。 磁头组件包括：记录磁极; 旋转扭矩振荡器，其具有第一和第二磁性层，以及介于所述第一和第二磁性层之间的中间层，所述自旋扭矩振荡器通过在所述第一和第二磁性层之间施加电流而产生高频磁场; 以及与第二磁性层的侧面的至少一部分相邻配置的第三磁性层。
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公开(公告)号：US08238060B2
公开(公告)日：2012-08-07
申请号：US12780269
申请日：2010-05-14
申请人： Kenichiro Yamada , Hitoshi Iwasaki , Junichi Akiyama , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu , Shuichi Murakami , Tadashi Kai
发明人： Kenichiro Yamada , Hitoshi Iwasaki , Junichi Akiyama , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu , Shuichi Murakami , Tadashi Kai
CPC分类号： G11B5/17 , G11B5/02 , G11B5/1278 , G11B5/3133 , G11B5/3146 , G11B2005/0002 , G11B2005/0024
摘要： A magnetic recording head includes: a main magnetic pole; a laminated body; and a pair of electrodes. The laminated body includes a first magnetic layer having a coercivity lower than magnetic field applied by the main magnetic pole, a second magnetic layer having a coercivity lower than the magnetic field applied by the main magnetic pole, and an intermediate layer provided between the first magnetic layer and the second magnetic layer. The pair of electrodes are operable to pass a current through the laminated body.
摘要翻译： 磁记录头包括：主磁极; 层压体; 和一对电极。 层叠体包括具有比由主磁极施加的磁场低的矫顽力的第一磁性层，具有低于由主磁极施加的磁场的矫顽力的第二磁性层，以及设置在第一磁性体之间的中间层 层和第二磁性层。 该对电极可操作以使电流通过层叠体。
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公开(公告)号：US08139322B2
公开(公告)日：2012-03-20
申请号：US12153490
申请日：2008-05-20
申请人： Kenichiro Yamada , Hitoshi Iwasaki , Junichi Akiyama , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu
发明人： Kenichiro Yamada , Hitoshi Iwasaki , Junichi Akiyama , Masayuki Takagishi , Tomomi Funayama , Masahiro Takashita , Mariko Shimizu
CPC分类号： G11B5/02 , G11B5/1278 , G11B5/314 , G11B5/3153 , G11B2005/0002
摘要： A magnetic recording head includes: a main magnetic pole; a laminated body; and a pair of electrodes operable to pass a current through the laminated body. The laminated body includes a first magnetic layer, a second magnetic layer, and an intermediate layer provided between the first magnetic layer and the second magnetic layer. A lamination direction of the laminated body is substantially parallel to a medium moving direction. In a first direction parallel to an air bearing surface and perpendicular to the lamination direction, the laminated body has a protruding portion that protrudes beyond an end of a surface of the main magnetic pole facing the laminated body.
摘要翻译： 磁记录头包括：主磁极; 层压体; 以及可操作以使电流通过层叠体的一对电极。 层叠体包括第一磁性层，第二磁性层和设置在第一磁性层和第二磁性层之间的中间层。 层叠体的层叠方向大致平行于介质移动方向。 在平行于空气轴承面并与层叠方向垂直的第一方向上，层叠体具有突出部，该突出部突出超过面对层叠体的主磁极的表面的端部。
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