发明申请
US20120095064A1 (PYRAZOL-3-YL)-1,3,4-THIADIAZOL-2-AMINE AND (PYRAZOL-3-YL)-1,3,4-THIAZOL-2-AMINE COMPOUNDS
失效
（PYRAZOL-3-YL）-1,3,4-噻二唑-2-胺和（吡唑-3-基）-1,3,4-三唑-2-胺化合物
- 专利标题： (PYRAZOL-3-YL)-1,3,4-THIADIAZOL-2-AMINE AND (PYRAZOL-3-YL)-1,3,4-THIAZOL-2-AMINE COMPOUNDS
- 专利标题（中）： （PYRAZOL-3-YL）-1,3,4-噻二唑-2-胺和（吡唑-3-基）-1,3,4-三唑-2-胺化合物
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申请号： US13264169申请日： 2010-04-13
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公开(公告)号： US20120095064A1公开(公告)日： 2012-04-19
- 发明人: Lluis Ballell Pages , Julia Castro Pichel , Raquel Fernandez Menendez , Esther Pilar Fernandez Velando , Silvia Gonzalez Del Valle , Maria Luisa Leon Diaz , Alfonso Mendoza Losana , Matthew James Wolfendale
- 申请人： Lluis Ballell Pages , Julia Castro Pichel , Raquel Fernandez Menendez , Esther Pilar Fernandez Velando , Silvia Gonzalez Del Valle , Maria Luisa Leon Diaz , Alfonso Mendoza Losana , Matthew James Wolfendale
- 优先权： EP09382049.6 20090413
- 国际申请： PCT/EP2010/002265 WO 20100413
- 主分类号： A61K31/433
- IPC分类号： A61K31/433 ; A61P31/06 ; C07D285/135
摘要：
A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
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