公开(公告)号：US08524750B2

公开(公告)日：2013-09-03

申请号：US13264169

申请日：2010-04-13

申请人： Lluis Ballell Pages ,  Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Maria Luisa Leon Diaz ,  Alfonso Mendoza Losana ,  Matthew James Wolfendale

发明人： Lluis Ballell Pages ,  Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Maria Luisa Leon Diaz ,  Alfonso Mendoza Losana ,  Matthew James Wolfendale

IPC分类号： A61K31/433 ,  A61K31/427 ,  A61K31/4155 ,  C07D285/135 ,  C07D231/16 ,  C07D417/14

CPC分类号： C07D417/14

摘要： A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

摘要翻译： 式（I）的化合物，其中：X是N，Y是CR5或X是C，Y是S; Z选自N和CH; R1选自H和Me; R2选自H，OH，OMe和Me; 每个R 3独立地选自C 1-3烷基，F，Cl，Br，CF 3和NH 2; R4选自Me，CF3，NO2和CHF2; R5选自H，Me和CHF 2; R6选自H和Me; 并且p为0-3，含有它们的组合物，它们在治疗中的用途，例如用于治疗结核病以及制备这些化合物的方法。

公开(公告)号：US20120095064A1

公开(公告)日：2012-04-19

申请号：US13264169

申请日：2010-04-13

申请人： Lluis Ballell Pages ,  Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Maria Luisa Leon Diaz ,  Alfonso Mendoza Losana ,  Matthew James Wolfendale

发明人： Lluis Ballell Pages ,  Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Maria Luisa Leon Diaz ,  Alfonso Mendoza Losana ,  Matthew James Wolfendale

IPC分类号： A61K31/433 ,  A61P31/06 ,  C07D285/135

CPC分类号： C07D417/14

摘要： A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is independently selected from C1-3alkyl, F, Cl, Br, CF3 and NH2; R4 is selected from Me, CF3, NO2 and CHF2; R5 is selected from H, Me and CHF2; R6 is selected from H and Me; and p is 0-3, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

摘要翻译： 式（I）的化合物，其中：X是N，Y是CR5或X是C，Y是S; Z选自N和CH; R1选自H和Me; R2选自H，OH，OMe和Me; 每个R 3独立地选自C 1-3烷基，F，Cl，Br，CF 3和NH 2; R4选自Me，CF3，NO2和CHF2; R5选自H，Me和CHF 2; R6选自H和Me; 并且p为0-3，含有它们的组合物，它们在治疗中的用途，例如用于治疗结核病以及制备这些化合物的方法。