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    3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS
    2.
    发明申请
    3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS 有权
    3-氨基吡唑衍生物应用于结核病

    公开(公告)号：US20130203802A1

    公开(公告)日：2013-08-08

    申请号：US13878889

    申请日：2011-10-11

    申请人： Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Araceli Mallo-Rubio

    发明人： Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Araceli Mallo-Rubio

    IPC分类号： C07D417/14 ,  C07D471/04

    CPC分类号： C07D417/14 ,  C07D471/04

    摘要： A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicyclic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

    摘要翻译： 式（I）的化合物或其药学上可接受的盐：其中：Het为5至10元杂芳环; X为N，Y为CR5; 或X为C，Y为S; Z选自N和CH; R1选自H和C1-2烷基; R2选自H，C1-2烷基，OH，-CH2OH和C1-2烷氧基; 每个R 3独立地选自OH，C 1-3烷基，F，Cl，Br，NH 2和C 1-3烷氧基; R 4选自C 1-3烷基和卤代C 1-3烷基; R 5选自H，C 1-3烷基和卤代C 1-3烷基; R6和R7各自独立地选自H，C 1-3烷基和C 1-3烷氧基; 或ii）R6和R7与它们所连接的环一起形成9元双环; p为0-3; 并且RA选自H和C 1-3烷基，含有它们的组合物，它们在治疗中的用途，例如用于治疗结核病以及制备这些化合物的方法。

    3-amino-pyrazole derivatives useful against tuberculosis
    3.
    发明授权
    3-amino-pyrazole derivatives useful against tuberculosis 有权
    可用于结核病的3-氨基 - 吡唑衍生物

    公开(公告)号：US08779153B2

    公开(公告)日：2014-07-15

    申请号：US13878889

    申请日：2011-10-11

    申请人： Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Araceli Mallo-Rubio

    发明人： Julia Castro Pichel ,  Raquel Fernandez Menendez ,  Esther Pilar Fernandez Velando ,  Silvia Gonzalez Del Valle ,  Araceli Mallo-Rubio

    IPC分类号： C07D285/135 ,  C07D277/10 ,  A61K31/44

    CPC分类号： C07D417/14 ,  C07D471/04

    摘要： A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

    摘要翻译： 式（I）的化合物或其药学上可接受的盐：其中：Het为5至10元杂芳环; X为N，Y为CR5; 或X为C，Y为S; Z选自N和CH; R1选自H和C1-2烷基; R2选自H，C1-2烷基，OH，-CH2OH和C1-2烷氧基; 每个R 3独立地选自OH，C 1-3烷基，F，Cl，Br，NH 2和C 1-3烷氧基; R 4选自C 1-3烷基和卤代C 1-3烷基; R 5选自H，C 1-3烷基和卤代C 1-3烷基; R6和R7各自独立地选自H，C 1-3烷基和C 1-3烷氧基; 或ii）R6和R7与它们所连接的环一起形成9元双环; p为0-3; 并且RA选自H和C 1-3烷基，含有它们的组合物，它们在治疗中的用途，例如用于治疗结核病以及制备这些化合物的方法。