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发明申请
US20120101152A1 NEURITE ELONGATION AGENT, MEMORY-IMPROVING AGENT AND ANTI-ALZHEIMER AGENT COMPRISING 4'-DEMETHYLNOBILETIN OR 4'-DEMETHYLTANGERETIN AS ACTIVE INGREDIENT, AND PROCESS FOR PRODUCTION OF THE COMPOUND 有权
神经延长剂，记忆改良剂和包含4'-去甲基胆碱或4'-去甲肾上腺素作为活性成分的抗 - 阿尔茨海默剂，以及该化合物的生产方法

  • 专利标题： NEURITE ELONGATION AGENT, MEMORY-IMPROVING AGENT AND ANTI-ALZHEIMER AGENT COMPRISING 4'-DEMETHYLNOBILETIN OR 4'-DEMETHYLTANGERETIN AS ACTIVE INGREDIENT, AND PROCESS FOR PRODUCTION OF THE COMPOUND
  • 专利标题（中）： 神经延长剂，记忆改良剂和包含4'-去甲基胆碱或4'-去甲肾上腺素作为活性成分的抗 - 阿尔茨海默剂，以及该化合物的生产方法
  • 申请号： US13321988
    申请日： 2010-03-10
  • 公开(公告)号： US20120101152A1
    公开(公告)日： 2012-04-26
  • 发明人: Shuichi Kusano , Hiroshi Tamura
  • 申请人： Shuichi Kusano , Hiroshi Tamura
  • 优先权： JP2009-133598 20090603
  • 国际申请： PCT/JP10/53958 WO 20100310
  • 主分类号： A61K31/352
  • IPC分类号： A61K31/352 ;  A61P25/00 ;  A61P25/28 ;  C12P17/06 ;  C07D311/30
NEURITE ELONGATION AGENT, MEMORY-IMPROVING AGENT AND ANTI-ALZHEIMER AGENT COMPRISING 4'-DEMETHYLNOBILETIN OR 4'-DEMETHYLTANGERETIN AS ACTIVE INGREDIENT, AND PROCESS FOR PRODUCTION OF THE COMPOUND
摘要：
A method for producing 4′-demethylnobiletin or 4′-demethyltangeretin including fermenting a skin derived from at least one citrus fruit selected from citrus fruits belonging to section Acrumen in subgenus Metacitrus in genus Citrus or citrus fruits belonging to section Aurantium in subgenus Archicitrus in genus Citrus, or a water extract product thereof using one or more Aspergillus molds selected from Aspergillus kawachii, Aspergillus awamori, Aspergillus oryzae, Aspergillus sojae, Aspergillus saitoi, and Aspergillus usamii to obtain a fermented product.
摘要（中）：

包括发酵至少一种柑橘类水果的皮肤的发酵方法，所述柑橘类水果选自属于属于属于属于属柑橘属亚属的柑橘类水果的柑橘类水果或属于亚属亚属中的to属部分的柑橘类水果 柑橘或其水提取产物，其使用选自曲霉（Aspergillus kawachii），泡盛曲霉（Aspergillus awamori），米曲霉（Aspergillus sojae），曲霉（Aspergillus sojae），saperi Aspergillus saitoi和美国曲霉（Aspergillus usamii）的一种或多种曲霉属霉菌，以获得发酵产物。

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