发明申请
US20120114618A1 Mesenchymal Stem Cells Producing Inhibitory RNA for Disease Modification
审中-公开
间充质干细胞产生抑制性RNA进行疾病修饰
- 专利标题： Mesenchymal Stem Cells Producing Inhibitory RNA for Disease Modification
- 专利标题（中）： 间充质干细胞产生抑制性RNA进行疾病修饰
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申请号： US13260551申请日： 2010-03-25
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公开(公告)号： US20120114618A1公开(公告)日： 2012-05-10
- 发明人: Jan A. Nolta , Scott Olson , Louisa Wirthlin
- 申请人： Jan A. Nolta , Scott Olson , Louisa Wirthlin
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 国际申请： PCT/US10/28712 WO 20100325
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; C12N5/10 ; A61P25/14 ; C12N5/0775
摘要：
Compositions and methods for delivering a siRNA, dsRNA, or miRNA polynucleotide into a target cell comprising contacting the target cell with a mesenchymal stem cell, which mesenchymal stem cell comprises an exogenous DNA sequence expressing the siRNA or dsRNA polynucleotide, thereby delivering the siRNA, dsRNA, or miRNA polynucleotide to the target cell through a cellular protrusion or a microvesicle.
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