发明申请
- 专利标题: AGENT FOR TREATMENT OR PREVENTION OF DISEASES ASSOCIATED WITH ACTIVITY OF NEUROTROPHIC FACTORS
- 专利标题(中): 治疗或预防与神经营养因子活动有关的疾病代理
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申请号: US13322888申请日: 2010-05-28
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公开(公告)号: US20120115856A1公开(公告)日: 2012-05-10
- 发明人: Junichi Ishikawa , Koichi Saito , Norihisa Ohe , Kentaro Kobayashi
- 申请人: Junichi Ishikawa , Koichi Saito , Norihisa Ohe , Kentaro Kobayashi
- 优先权: JP2009-131333 20090529
- 国际申请: PCT/JP10/03622 WO 20100528
- 主分类号: A61K31/428
- IPC分类号: A61K31/428 ; C07D403/10 ; C07D413/10 ; C07D413/14 ; C07D403/14 ; C07D417/14 ; A61K31/4184 ; A61K31/423 ; A61K31/4439 ; A61K31/454 ; A61K31/541 ; A61K31/5377 ; A61P9/10 ; A61P25/02 ; C07D417/10
摘要:
A compound depicted by the formula below, or a pharmaceutically acceptable salt or solvate thereof. wherein, R1 represents (1) a C3-6 alkyl group, (2) a C1-6 alkyl group substituted with one or more substituent group(s) selected from those consisting a halogen atom, etc., (3) a C3-10 non-aromatic cyclic hydrocarbon group or a 5- to 6-membered non-aromatic heterocyclic group which respectively is optionally substituted with one or more substituent group(s) selected from those consisting an oxo group, etc., (4) an aromatic cyclic hydrocarbon group substituted with one or more substituent selected from the group consisting halogen atom and C1-4 alkoxy group; X represents NH, O, or S; Y represents CH or N; Z represents N or a C—R2; R2 represents (1) hydrogen atom, (2) a C1-6 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group that respectively is optionally substituted with one or more substituent group(s) selected from among those consisting (a) a halogen atom, etc., or (3) a C5-6 non-aromatic cyclic hydrocarbon group or a 5- to 6-membered non-aromatic heterocyclic group optionally substituted; ring A represents a benzene ring optionally substituted; ring B represents a benzene ring optionally substituted.