发明申请
- 专利标题： NEW CLASS OF HISTONE DEACETYLASE INHIBITORS
- 专利标题（中）： 新一类脱乙酰壳多糖酶抑制剂
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申请号： US13100670申请日： 2011-05-04
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公开(公告)号： US20120115867A1公开(公告)日： 2012-05-10
- 发明人: Saverio Minucci , Pier Giuseppe Pelicci , Antonello Mai , Marco Ballarini , Gaetano Gargiulo , Silvio Massa , Florian Thaler , Gilles Pain , Andrea Colombo , Stefania Gagliardi , Mario Varasi , Ciro Mercurio
- 申请人： Saverio Minucci , Pier Giuseppe Pelicci , Antonello Mai , Marco Ballarini , Gaetano Gargiulo , Silvio Massa , Florian Thaler , Gilles Pain , Andrea Colombo , Stefania Gagliardi , Mario Varasi , Ciro Mercurio
- 申请人地址： IT Milano
- 专利权人： DAC S.R.L.
- 当前专利权人： DAC S.R.L.
- 当前专利权人地址： IT Milano
- 优先权： ITMI2004A001869 20041001; DK2004-01519 20041005; ITMI2006A000621 20060331; EP07115103.9 20070828
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; C07D401/10 ; A61P35/00 ; C07D413/06 ; A61K31/5377 ; C07D295/155 ; A61K31/496
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: Q is a bond, CH2, NR5 or oxygen, X is CH or nitrogen, Y is a bond, CH2, oxygen or NR6, Z is CH or nitrogen, R1, R2 are, independently, hydrogen or C1-C6 alkyl, R3, R4 are, independently, hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl or C1-C6 haloalkoxy, and R5 and R6 are as further defined in the specification, and pharmaceutical acceptable salts thereof.
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