Invention Application
US20120121517A1 BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE)-SUPERPARAMAGNETIC NANOPARTICLE COMPLEX, PREPARATION METHOD AND USE THEREOF
有权
生物可降解和耐热聚合物（有机磷） - 巯基丙烯酸纳米复合物，制备方法及其用途
- Patent Title: BIODEGRADABLE AND THERMOSENSITIVE POLY(ORGANOPHOSPHAZENE)-SUPERPARAMAGNETIC NANOPARTICLE COMPLEX, PREPARATION METHOD AND USE THEREOF
- Patent Title (中): 生物可降解和耐热聚合物（有机磷） - 巯基丙烯酸纳米复合物，制备方法及其用途
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Application No.: US13173756Application Date: 2011-06-30
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Publication No.: US20120121517A1Publication Date: 2012-05-17
- Inventor: Soo-Chang SONG , Jang Il KIM
- Applicant: Soo-Chang SONG , Jang Il KIM
- Assignee: Korean Institute of Science and Technology of Seoul, Republic of Korea
- Current Assignee: Korean Institute of Science and Technology of Seoul, Republic of Korea
- Priority: KR10-2010-0062850 20100630
- Main IPC: A61K49/12
- IPC: A61K49/12 ; C08G79/02 ; A61K49/14 ; A61P35/00 ; C08G63/692 ; A61K47/48 ; B82Y30/00 ; B82Y5/00 ; B82Y25/00
Abstract:
The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T-2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.
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