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18 条记录 (耗时 0.029 秒)

    Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof
    5.
    发明授权
    Biodegradable and thermosensitive poly(organophosphazene)-superparamagnetic nanoparticle complex, preparation method and use thereof 有权
    可生物降解和热敏聚（有机膦腈） - 超顺磁纳米颗粒复合物，其制备方法和用途

    公开(公告)号：US09017726B2

    公开(公告)日：2015-04-28

    申请号：US13173756

    申请日：2011-06-30

    申请人： Soo-Chang Song ,  Jang Il Kim

    发明人： Soo-Chang Song ,  Jang Il Kim

    IPC分类号： A61K9/14 ,  B82Y5/00 ,  A61K9/00 ,  A61K49/18 ,  B82Y15/00 ,  C08G79/02 ,  C08L85/02

    CPC分类号： B82Y5/00 ,  A61K9/0009 ,  A61K49/1857 ,  B82Y15/00 ,  C08G79/025 ,  C08K3/22 ,  C08K2003/2265 ,  C08L85/02 ,  Y02A50/401

    摘要： The present invention relates to a poly(organophosphazene)-superparamagnetic nanoparticle complex including a biodegradable and thermosensitive poly(organophosphazene) and a iron oxide (Fe3O4, Magnetite)-series ferrite superparamagnetic nanoparticle, a preparation method, and uses of carrying a physiologically-active material, a bio-material and a biomaterial for cancer hyperthermia. The iron oxide is used as a MRI contrast agent for T−2 and T2* weighted image, and the poly(organophosphazene) shows a sol-to-gel behavior depending upon the temperature change. The complex is a bound-type where the superparamagnetic ferrite nanoparticle is bonded to phosphazene-based polymer via hydrophobic binding, and a mixed-type where the superparamagnetic ferrite nanoparticle is physically mixed with the phosphazene-based polymer.

    摘要翻译： 本发明涉及包含可生物降解和热敏聚（有机膦腈）和氧化铁（Fe 3 O 4，磁铁矿）系列铁氧体超顺磁性纳米颗粒的聚（有机膦腈） - 超顺磁性纳米颗粒络合物，其制备方法和携带生理活性 材料，生物材料和癌症热疗的生物材料。 氧化铁用作T-2和T2 *加权图像的MRI造影剂，聚（有机膦腈）根据温度变化显示溶胶 - 凝胶行为。 复合物是超顺磁性铁氧体纳米颗粒通过疏水结合与磷腈基聚合物结合的结合型，以及超顺磁性铁氧体纳米颗粒与磷腈基聚合物物理混合的混合型。

    Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof
    7.
    发明申请
    Biodegradable and Thermosensitive Poly(Organophosphazene) Hydrogel, Preparation Method Thereof and Use Thereof 有权
    可生物降解和热敏聚（有机膦腈）水凝胶，其制备方法及用途

    公开(公告)号：US20090022683A1

    公开(公告)日：2009-01-22

    申请号：US11568851

    申请日：2006-11-03

    申请人： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

    发明人： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

    IPC分类号： A61K38/00 ,  C08G79/02 ,  A61K9/00 ,  A61K38/02 ,  A61K39/00 ,  A61K48/00 ,  A61K47/30 ,  A61K38/21 ,  A61K38/26 ,  A61K38/18 ,  A61K38/20 ,  A61K38/28 ,  A61K38/22 ,  A61K38/23 ,  A61K38/27 ,  A61K39/395 ,  A61K39/29 ,  A61K31/337 ,  A61K31/704

    CPC分类号： A61K9/06 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/34 ,  A61K47/6903 ,  C08G79/025

    摘要： The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

    摘要翻译： 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。

    Thermosensitive cyclotriphosphazene-platinum complex conjugate, its preparation method and anticancer agent containing the same
    9.
    发明授权
    Thermosensitive cyclotriphosphazene-platinum complex conjugate, its preparation method and anticancer agent containing the same 失效
    热敏环磷腈 - 铂络合物缀合物及其制备方法和含有它的抗癌剂

    公开(公告)号：US06333422B1

    公开(公告)日：2001-12-25

    申请号：US09771716

    申请日：2001-01-30

    申请人： Youn Soo Sohn ,  Soo-Chang Song ,  Sang Beom Lee

    发明人： Youn Soo Sohn ,  Soo-Chang Song ,  Sang Beom Lee

    IPC分类号： C07F906

    CPC分类号： C07F9/65815 ,  C07F15/0093

    摘要： The present invention provides a novel thermosensitive cyclotriphosphazene-platinum complex conjugates represented by Formula 1, wherein m is a repeating unit of poly(alkoxyethylene glycol) selected from the integers 2, 7 and 12; n represents the length of the alkyl chain selected from the integers 0, 1, 2 and 3; x represents the length of the anionic amino acid residue selected from the integers 0 (amino malonic acid derivatives), 1 (aspartic acid derivatives) and 2 (glutamic acid derivatives); A2 is a bidentate chelating diamine selected from the group consisting of 2,2-dimethyl-1,3-propanediamine (dmpda), trans(±)-1,2-diaminocyclohexane (dach) and 1,1-diaminomethylcyclohexane (dmach).

    摘要翻译： 本发明提供了由式1表示的新型热敏环三磷腈 - 铂络合物缀合物，其中m是选自整数2，7和12的聚（烷氧基乙二醇）的重复单元; n表示选自整数0,1,2和3的烷基链的长度; x表示选自整数0（氨基丙二酸衍生物），1（天冬氨酸衍生物）和2（谷氨酸衍生物）的阴离子氨基酸残基的长度; A2是选自2,2-二甲基-1,3-丙二胺（dmpda），反式（±）-1,2-二氨基环己烷（dach）和1,1-二氨基甲基环己烷（dmach）的二齿螯合二胺。