发明申请
- 专利标题: POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS
- 专利标题(中): 用于治疗与心血管,代谢和炎症疾病相关的疾病的多重脂肪酸
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申请号: US13319101申请日: 2010-05-07
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公开(公告)号: US20120122940A1公开(公告)日: 2012-05-17
- 发明人: Ragnar Hovland , Anne Kristin Holmeide , Tore Skjæret , Morten Brændvang
- 申请人: Ragnar Hovland , Anne Kristin Holmeide , Tore Skjæret , Morten Brændvang
- 国际申请: PCT/IB10/01251 WO 20100507
- 主分类号: A61K31/19
- IPC分类号: A61K31/19 ; C07C69/734 ; A61K31/22 ; C07D263/26 ; A61K31/421 ; A61P29/00 ; A61P1/00 ; A61P9/10 ; A61P3/10 ; A61P7/00 ; A61P3/06 ; A61P3/04 ; C07C51/42 ; C07C67/48 ; C07C57/03
摘要:
The present disclosure relates to lipid compounds of the general formula (I): R1-O—C(R2)(R3)-X (I) wherein R1 is a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, or a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.