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公开(公告)号:US20230023607A1
公开(公告)日:2023-01-26
申请号:US17790831
申请日:2021-02-04
发明人: Wei Wang
IPC分类号: C07D493/04 , C07D493/14 , C07D413/06 , C07D263/26
摘要: Disclosed are a deuterated compound of fomula (I), or a salt thereof, and methods for preparation thereof. The present disclosure may provide a mild, versatile organophotoredox method for the preparation of diverse, enantioenriched α-deuterated α-amino acids. In particular, the present disclosure may address the long-standing challenge of installing sterically demanding side chains into α-amino acids, including late-stage modifications on medicinal agents and natural products.
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公开(公告)号:US20220204540A1
公开(公告)日:2022-06-30
申请号:US17604892
申请日:2020-04-28
申请人: ISAGRO S.p.A.
发明人: Marilena GUSMEROLI , Giuseppe D'ORAZIO , Entela SINANI , Daniele FORGIA , Paolo BELLANDI , Chiara SARGIOTTO , Daniele BIANCHI , Jessica VILLATA , Riccardo LIGUORI
IPC分类号: C07F9/6574 , C07F9/40 , C07D207/16 , C07D211/60 , C07D211/78 , C07D233/02 , C07D285/12 , C07D279/06 , C07D277/14 , C07D277/06 , C07D277/56 , C07D263/06 , C07D263/24 , C07D263/34 , C07D263/26 , A01N57/24 , A01N47/16 , A01N43/76 , A01N43/86 , A01N43/50 , A01N43/82 , A01N43/78 , A01N43/40 , A01N43/36
摘要: Non-aromatic fluoroalkenyl heterocyclic compounds having general formula (I), agronomic compositions containing said compounds having formula (I) and their use for the control of nematodes in agricultural crops, are described.
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公开(公告)号:US11178873B2
公开(公告)日:2021-11-23
申请号:US15747180
申请日:2016-07-15
申请人: FMC CORPORATION
IPC分类号: A01N47/38 , C07D233/38 , C07D207/26 , C07D207/27 , C07D263/26
摘要: Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, (Formula (1)) wherein G, J, Q1, R4, Y2, Q2, R5 and Y1 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.
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公开(公告)号:US10752605B2
公开(公告)日:2020-08-25
申请号:US16417664
申请日:2019-05-21
申请人: CORSAIR PHARMA, INC.
IPC分类号: C07D313/00 , C07C69/712 , C07D317/40 , C07D321/00 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07D453/02 , C07C59/54 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34 , A61K9/70 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31
摘要: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号:US20190330180A1
公开(公告)日:2019-10-31
申请号:US16097106
申请日:2017-04-24
发明人: Helmars SMITS , Sujit Kumar GHORAI
IPC分类号: C07D401/04 , C07D213/75 , C07D263/26
摘要: The present invention relates to a process for the preparation of a compound of formula wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification.
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公开(公告)号:US10414736B2
公开(公告)日:2019-09-17
申请号:US16146129
申请日:2018-09-28
发明人: Phil Ho Lee , Koo Yeon Lee , Yonghyeon Baek , Kyusik Um , Byeong Su Kim
IPC分类号: C07D263/26 , C07D205/08 , B01J31/38 , B01J31/22
摘要: Disclosed is a method of preparing ezetimibe, including cross-metathesis using a Grubbs 2nd catalyst and deprotection using a Pearlman's catalyst, and an intermediate thereof. The method of preparing ezetimibe is useful as an efficient ezetimibe synthesis technique in pharmaceutical fields using ezetimibe as a raw material.
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公开(公告)号:US20190031607A1
公开(公告)日:2019-01-31
申请号:US16150070
申请日:2018-10-02
发明人: Jean-Christophe ANDREZ , Philippe BERGERON , Paul Robert BICHLER , Sultan CHOWDHURY , Christoph Martin DEHNHARDT , Thilo FOCKEN , Wei GONG , Michael Edward GRIMWOOD , Abid HASAN , Ivan William HEMEON , Qi JIA , Brian Salvatore SAFINA , Shaoyi SUN , Michael Scott WILSON , Alla Yurevna ZENOVA
IPC分类号: C07D207/16 , C07C235/52 , C07D209/02 , C07D401/10 , C07D205/04 , C07D207/22 , C07D211/20 , C07C235/42 , C07D211/38 , C07D409/06 , C07D265/30 , C07D413/12 , C07D263/26 , C07C235/54 , C07D417/12 , C07D305/08 , C07D213/69 , C07D403/04 , C07D231/06 , C07D209/52 , C07D221/22 , C07D209/54 , C07D403/12 , C07D211/60 , C07D207/10 , C07D401/12 , C07D471/08 , C07D413/14 , C07D207/08 , C07D405/10 , C07D403/14 , C07D451/02 , C07D401/14 , C07D263/04 , C07D277/06
CPC分类号: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
摘要: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号:US09845305B2
公开(公告)日:2017-12-19
申请号:US15296164
申请日:2016-10-18
申请人: Corsair Pharma Inc.
发明人: Cyrus K. Becker , Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
IPC分类号: C07D321/00 , C07D307/20 , C07D317/40 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
CPC分类号: C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02
摘要: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.
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9.
公开(公告)号:US20170339961A1
公开(公告)日:2017-11-30
申请号:US15679415
申请日:2017-08-17
申请人: Dow AgroSciences LLC
发明人: Ronald J. Heemstra , Ronald Ross, JR. , Kyle A. DeKorver , Kaitlyn Gray , Daniel I. Knueppel , Peter Vednor , Timothy P. Martin , Joseph D. Eckelbarger , John F. Daeuble, SR. , Ricky Hunter , David A. Demeter , Tony K. Trullinger , Erich W. Baum , Zoltan L. Benko , Nakyen Choy , Gary D. Crouse , Fangzheng Li , Jeffrey Nissen , Monica B. Olson , Michelle Riener , Thomas C. Sparks , Frank J. Wessels , Maurice C. Yap
IPC分类号: A01N53/00 , C07D487/04 , C07D333/60 , C07D333/48 , C07D333/36 , C07D331/04 , C07D309/14 , C07D307/52 , C07D307/33 , C07D305/08 , C07D295/32 , C07D285/06 , C07D277/36 , C07D277/30 , C07D263/26 , C07D261/12 , C07D253/07 , C07D249/08 , C07D241/20 , C07D235/30 , C07D233/80 , C07D233/36 , C07D231/56 , C07D231/12 , C07D215/38 , C07D215/227 , C07D213/89 , C07D213/84 , C07D213/81 , C07D213/75 , C07D213/56 , C07D209/49 , C07D207/452 , C07D207/273 , C07D207/10 , C07D205/04 , C07C381/10 , C07C331/12 , C07C323/59 , C07C323/42 , C07C323/41 , C07C317/50 , C07C317/40 , C07C317/28 , C07C317/14 , C07C311/46 , C07C311/08 , C07C271/66 , C07C271/28 , C07C259/10 , C07C255/60 , C07C255/57 , C07C255/46 , C07C255/29 , C07C237/42 , C07C237/22 , C07C233/65 , C07C233/63 , A01N43/90 , A01N43/82 , A01N43/707 , A01N43/653 , A01N43/60 , A01N43/40 , A01N41/10 , A01N37/34 , A01N37/22 , C07C2601/14 , C07C2601/08 , C07C2601/02 , C07C2601/04
CPC分类号: A01N53/00 , A01N37/22 , A01N37/34 , A01N41/10 , A01N43/40 , A01N43/60 , A01N43/653 , A01N43/707 , A01N43/82 , A01N43/90 , C07C233/63 , C07C233/65 , C07C237/22 , C07C237/42 , C07C255/29 , C07C255/46 , C07C255/57 , C07C255/60 , C07C259/10 , C07C271/28 , C07C271/66 , C07C311/08 , C07C311/46 , C07C317/14 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07C331/12 , C07C381/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/273 , C07D207/452 , C07D209/49 , C07D213/56 , C07D213/75 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/227 , C07D215/38 , C07D231/12 , C07D231/56 , C07D233/36 , C07D233/80 , C07D235/30 , C07D241/20 , C07D249/08 , C07D253/07 , C07D261/12 , C07D263/26 , C07D277/30 , C07D277/36 , C07D285/06 , C07D295/32 , C07D305/08 , C07D307/33 , C07D307/52 , C07D309/14 , C07D331/04 , C07D333/36 , C07D333/48 , C07D333/60 , C07D487/04
摘要: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
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公开(公告)号:US09637462B2
公开(公告)日:2017-05-02
申请号:US15034751
申请日:2014-11-05
IPC分类号: C07D263/26 , C07D275/06 , C07D233/82 , C07C41/22 , C07D233/74 , C07D263/22 , C07D209/48 , C07C17/093 , C07C29/64 , C07C41/05 , C07C67/05 , C07C201/12 , C07D211/38 , C07C17/10 , C07C17/12 , C07C17/14 , C07C17/363 , C07B39/00 , C07D207/46
CPC分类号: C07D263/26 , C07B39/00 , C07C17/093 , C07C17/10 , C07C17/12 , C07C17/14 , C07C17/363 , C07C29/64 , C07C41/05 , C07C41/22 , C07C67/05 , C07C201/12 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07D207/46 , C07D209/48 , C07D211/38 , C07D233/74 , C07D233/82 , C07D263/22 , C07D275/06 , C07C43/225 , C07C35/48 , C07C43/192 , C07C33/46 , C07C43/174 , C07C69/63 , C07C22/04 , C07C25/02 , C07C205/12 , C07C25/13 , C07C205/11 , C07C23/10 , C07C23/28 , C07C23/08 , C07C23/14 , C07C23/16 , C07C19/07
摘要: The present invention provides new stable crystalline N-iodoamides-1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organic iodides using N-iodoamides of this invention and recovery of the amide co-products from waste water.
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