发明申请
- 专利标题： POLYNUCLEOTIDES ENCODING NOVEL PCSK9 VARIANTS
- 专利标题（中）： 多核苷酸编码新的PCSK9变体
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申请号： US13336371申请日： 2011-12-23
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公开(公告)号： US20120129237A1公开(公告)日： 2012-05-24
- 发明人: Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
- 申请人： Gabriel A. Mintier , Jian Chen , John N. Feder , Bowman Miao , Rex Arnold Parker
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： C12N9/64
- IPC分类号： C12N9/64 ; C12N9/96
摘要：
The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
公开/授权文献
- US08354264B2 Polynucleotides encoding novel PCSK9 variants 公开/授权日：2013-01-15