公开(公告)号：US08105804B2

公开(公告)日：2012-01-31

申请号：US12903658

申请日：2010-10-13

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12P21/06 ,  C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20110076742A1

公开(公告)日：2011-03-31

申请号：US12903658

申请日：2010-10-13

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12N9/50 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于与这些多肽相关的各种疾病和/或病症的诊断，治疗和/或预防的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07846706B2

公开(公告)日：2010-12-07

申请号：US12456798

申请日：2009-06-23

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20100003736A1

公开(公告)日：2010-01-07

申请号：US12456798

申请日：2009-06-23

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/50 ,  C12N9/96

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US08354264B2

公开(公告)日：2013-01-15

申请号：US13336371

申请日：2011-12-23

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

公开(公告)号：US20120129237A1

公开(公告)日：2012-05-24

申请号：US13336371

申请日：2011-12-23

申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/64 ,  C12N9/96

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07572618B2

公开(公告)日：2009-08-11

申请号：US11824461

申请日：2007-06-28

申请人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

发明人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

IPC分类号： C12N9/50 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US20080008697A1

公开(公告)日：2008-01-10

申请号：US11824461

申请日：2007-06-28

申请人： Gabriel Mintier ,  Jian Chen ,  John Feder ,  Bowman Miao ,  Rex Parker

发明人： Gabriel Mintier ,  Jian Chen ,  John Feder ,  Bowman Miao ,  Rex Parker

IPC分类号： C12N15/12 ,  A61K38/17 ,  A61K38/48 ,  C12N15/63 ,  C12P21/02 ,  G01N33/68 ,  C12Q1/68 ,  C12N9/50 ,  C07K14/435 ,  C12N1/00

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US08420098B2

公开(公告)日：2013-04-16

申请号：US13085864

申请日：2011-04-13

申请人： Ray Camphausen ,  Jonathan H. Davis ,  Sharon T. Cload ,  Fabienne M. Denhez ,  Amna Saeed-Kothe ,  Dasa Lipovsek ,  Ching-Hsiung Frederick Lo ,  Chee Meng Low ,  Bowman Miao ,  Tracy S. Mitchell ,  Rex A. Parker ,  Ginger C. Rakestraw ,  Katie A. Russo ,  Doree F. Sitkoff

发明人： Ray Camphausen ,  Jonathan H. Davis ,  Sharon T. Cload ,  Fabienne M. Denhez ,  Amna Saeed-Kothe ,  Dasa Lipovsek ,  Ching-Hsiung Frederick Lo ,  Chee Meng Low ,  Bowman Miao ,  Tracy S. Mitchell ,  Rex A. Parker ,  Ginger C. Rakestraw ,  Katie A. Russo ,  Doree F. Sitkoff

IPC分类号： A61K39/00 ,  C07K1/00

CPC分类号： C07K14/78 ,  A61K38/39 ,  A61K47/549 ,  A61K47/60 ,  C07K16/18 ,  C07K16/40 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/70 ,  C12N9/6424

摘要： The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.

摘要翻译： 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这些蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。

公开(公告)号：US20120094909A1

公开(公告)日：2012-04-19

申请号：US13085864

申请日：2011-04-13

申请人： Ray Camphausen ,  Jonathan H. Davis ,  Sharon T. Cload ,  Fabienne M. Denhez ,  Amna Saeed-Kothe ,  Dasa Lipovsek ,  Ching-Hsiung Frederick Lo ,  Chee Meng Low ,  Bowman Miao ,  Tracy S. Mitchell ,  Rex A. Parker ,  Ginger C. Rakestraw ,  Katie A. Russo ,  Doree F. Sitkoff

发明人： Ray Camphausen ,  Jonathan H. Davis ,  Sharon T. Cload ,  Fabienne M. Denhez ,  Amna Saeed-Kothe ,  Dasa Lipovsek ,  Ching-Hsiung Frederick Lo ,  Chee Meng Low ,  Bowman Miao ,  Tracy S. Mitchell ,  Rex A. Parker ,  Ginger C. Rakestraw ,  Katie A. Russo ,  Doree F. Sitkoff

IPC分类号： C07K19/00 ,  A61K38/39

CPC分类号： C07K14/78 ,  A61K38/39 ,  A61K47/549 ,  A61K47/60 ,  C07K16/18 ,  C07K16/40 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/70 ,  C12N9/6424

摘要： The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.

摘要翻译： 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。