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    PCSK9 polypeptides
    3.
    发明授权
    PCSK9 polypeptides 有权
    PCSK9多肽

    公开(公告)号：US07846706B2

    公开(公告)日：2010-12-07

    申请号：US12456798

    申请日：2009-06-23

    申请人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  John N. Feder ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/00 ,  C12N9/50 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel human G-protein coupled receptor splice variant, HGPRBMY29SV2
    4.
    发明授权
    Polynucleotides encoding a novel human G-protein coupled receptor splice variant, HGPRBMY29SV2 有权
    编码新型人G蛋白偶联受体剪接变体的多核苷酸HGPRBMY29SV2

    公开(公告)号：US07276354B2

    公开(公告)日：2007-10-02

    申请号：US11071761

    申请日：2005-03-03

    申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

    发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C12N15/74 ,  C12N1/20

    CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1
    5.
    发明授权
    Polynucleotides encoding a novel human G-protein coupled receptor splice variant HGPRBMY29sv1 有权
    编码新型人G蛋白偶联受体剪接变体HGPRBMY29sv1的多核苷酸

    公开(公告)号：US07049096B2

    公开(公告)日：2006-05-23

    申请号：US10120604

    申请日：2002-04-11

    申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol ,  Donald R. Hawken

    发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David Bol ,  Donald R. Hawken

    IPC分类号： C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N15/74 ,  C07H21/04

    CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2)
    6.
    发明授权
    Splice variants of human G-protein coupled receptor HGPRBMY29 (HGPRMBY29SV2) 有权
    人G蛋白偶联受体HGPRBMY29（HGPRBMY29SV2）的剪接变体

    公开(公告)号：US08124729B2

    公开(公告)日：2012-02-28

    申请号：US11891240

    申请日：2007-08-09

    申请人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David K. Bol ,  Donald R. Hawken

    发明人： John N. Feder ,  Chandra S. Ramanathan ,  Gabriel A. Mintier ,  David K. Bol ,  Donald R. Hawken

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C12P21/06 ,  C12N1/20 ,  C12N15/74

    CPC分类号： A61K49/0008 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S435/975

    摘要： The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码HGPRBMY28和HGPRBMY29多肽的新型多核苷酸，其片段及其同源物。 本发明还提供编码HGPRBMY29多肽，HGPRBMY29v1和HGPRBMY29v2的剪接变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY28，HGPRBMY29，HGPRBMY29v1和HGPRBMY29v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel PCSK9 variants
    8.
    发明授权
    Polynucleotides encoding novel PCSK9 variants 有权
    编码新型PCSK9变体的多核苷酸

    公开(公告)号：US07572618B2

    公开(公告)日：2009-08-11

    申请号：US11824461

    申请日：2007-06-28

    申请人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

    发明人： Gabriel A. Mintier ,  Jian Chen ,  Bowman Miao ,  Rex Arnold Parker

    IPC分类号： C12N9/50 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K2317/41 ,  C07K2317/76 ,  C12N9/6424 ,  C12Y302/01008 ,  C12Y304/21061 ,  Y10T436/143333

    摘要： The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码PCSK9b和PCSK9c多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型PCSK9b和PCSK9c多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。