发明申请
- 专利标题： Compounds and Compositions for Use in Phototherapy and in Treatment of Ocular Neovascular Disease and Cancers
- 专利标题（中）： 用于光疗和眼部新生血管疾病和癌症治疗的化合物和组合物
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申请号： US13383243申请日： 2010-07-16
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公开(公告)号： US20120129879A1公开(公告)日： 2012-05-24
- 发明人: Gary L. Cantrell , Raghavan Rajagopalan , David W. Berberich , Amolkumar Karwa , Richard B. Dorshow
- 申请人： Gary L. Cantrell , Raghavan Rajagopalan , David W. Berberich , Amolkumar Karwa , Richard B. Dorshow
- 国际申请： PCT/US10/42218 WO 20100716
- 主分类号： A61K31/485
- IPC分类号： A61K31/485 ; A61P35/00 ; C07D221/28 ; A61P27/02 ; C07D489/02 ; C07D489/00
摘要：
The invention relates generally to anti-angiogenesis agents and related methods of using to anti-angiogenesis agents for biomedical applications including direct monotherapy and combination therapy for treatment of an angiogenesis related condition. In an embodiment, the invention provides a class of opioid compounds and structurally related opioid derivatives exhibiting anti-VEGF activity for use in therapeutic procedures, including phototherapy. Opioid compounds and structurally related opioid derivatives of the invention may be administered alone or in combination with administration of a phototherapy agent and/or other therapeutic agent.
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