发明申请
- 专利标题： SECRETED AP2 AND METHODS OF INHIBITING SAME
- 专利标题（中）： 分泌AP2及其抑制方法
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申请号： US13203880申请日： 2010-03-05
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公开(公告)号： US20120134998A1公开(公告)日： 2012-05-31
- 发明人: Gokhan S. Hotamisligil , Haiming Cao
- 申请人： Gokhan S. Hotamisligil , Haiming Cao
- 申请人地址： US MA Cambridge
- 专利权人： President and Fellows of Harvard College
- 当前专利权人： President and Fellows of Harvard College
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2010/026305 WO 20100305
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P3/00 ; A61P3/04 ; A61P25/00 ; A61P1/16 ; A61P9/10 ; A61P11/06 ; A61P9/12 ; G01N33/566 ; A61P3/10
摘要：
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.
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