发明申请
- 专利标题: USE OF 2,5-DIHYDROXYBENZENESULFONIC ACID IN THE MANUFACTURING OF MEDICINES, APPLICABLE TO THE TREATMENT OF ANGIODEPENDENT DISEASES
- 专利标题(中): 2,5-二羟基苯甲酸在制造药物中的应用,适用于治疗感染性疾病
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申请号: US13169781申请日: 2011-06-27
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公开(公告)号: US20120142780A1公开(公告)日: 2012-06-07
- 发明人: Pedro Cuevas Sanchez , Antonio Romero Garrido , Guillermo Gimenez Gallego , Serafín Valverde Lopez , Rosa María Lozano Puerto
- 申请人: Pedro Cuevas Sanchez , Antonio Romero Garrido , Guillermo Gimenez Gallego , Serafín Valverde Lopez , Rosa María Lozano Puerto
- 申请人地址: ES Madrid
- 专利权人: Action Medicines
- 当前专利权人: Action Medicines
- 当前专利权人地址: ES Madrid
- 优先权: ESP200400371 20040217
- 主分类号: A61K31/185
- IPC分类号: A61K31/185 ; A61P17/12 ; A61P17/06
摘要:
The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques.
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