公开(公告)号：US20120142780A1

公开(公告)日：2012-06-07

申请号：US13169781

申请日：2011-06-27

申请人： Pedro Cuevas Sanchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafín Valverde Lopez ,  Rosa María Lozano Puerto

发明人： Pedro Cuevas Sanchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafín Valverde Lopez ,  Rosa María Lozano Puerto

IPC分类号： A61K31/185 ,  A61P17/12 ,  A61P17/06

CPC分类号： A61K31/185

摘要： The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques.

摘要翻译： 本发明涉及2,5-二羟基苯磺酸在制备用于治疗依赖性疾病的药物中的用途。 更具体地，本发明涉及上述化合物，特别是其钙和钾盐用于治疗呈现细胞凋亡降低（即癌症和牛皮癣）的两种血液依赖性疾病的用途。 本发明还公开了所述家族化合物在非静止细胞中的抗增殖，抗微生物，抗血管生成和促凋亡能力。 此外，本发明详细描述了所述化合物对已知的细胞生长抑制药物在治疗肿瘤中，特别是胶质瘤的增强作用。 本发明进一步涉及所述化合物在治疗慢性银屑病斑块的基础上结合抗增生性，抗血管生成和促血细胞生成能力的治疗功效。

公开(公告)号：US07968531B2

公开(公告)日：2011-06-28

申请号：US10588166

申请日：2005-02-16

申请人： Pedro Cuevas Sanchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafín Valverde Lopez ,  Rosa María Lozano Puerto

发明人： Pedro Cuevas Sanchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafín Valverde Lopez ,  Rosa María Lozano Puerto

IPC分类号： A61K31/185 ,  A61K31/56 ,  A01N37/00 ,  A01N45/00

CPC分类号： A61K31/185

摘要： The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapoptotic capacities thereof, in the treatment of chronic psoriatic plaques.

摘要翻译： 本发明涉及2,5-二羟基苯磺酸在制备用于治疗依赖性疾病的药物中的用途。 更具体地，本发明涉及上述化合物，特别是其钙和钾盐用于治疗呈现细胞凋亡降低（即癌症和牛皮癣）的两种血液依赖性疾病的用途。 本发明还公开了所述家族化合物在非静止细胞中的抗增殖，抗微生物，抗血管生成和促凋亡能力。 此外，本发明详细描述了所述化合物对已知的细胞生长抑制药物在治疗肿瘤中，特别是胶质瘤的增强作用。 本发明进一步涉及所述化合物在治疗慢性银屑病斑块的基础上结合抗增殖，抗血管生成和促凋亡能力的治疗功效。

公开(公告)号：US20120077785A1

公开(公告)日：2012-03-29

申请号：US13231630

申请日：2011-09-13

申请人： Pedro Cuevas Sanchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafín Valverde Lopez ,  Rosa María Lozano Puerto

发明人： Pedro Cuevas Sanchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafín Valverde Lopez ,  Rosa María Lozano Puerto

IPC分类号： A61K31/185 ,  A61K31/60 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P17/06 ,  A61P31/00 ,  A61P17/18 ,  A61P29/00 ,  A61K31/59 ,  A61P17/00

CPC分类号： A61K31/185 ,  A61K9/0014 ,  A61K31/095 ,  A61K31/56 ,  A61K31/59 ,  A61K31/60 ,  A61K45/06 ,  C07C309/29

摘要： The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent. In the invention the 2,5-dihydroxybenzene sulfonic acid compounds or pharmaceutically acceptable salts thereof are 2,5-dihydroxybenzene sulfonic acid, calcium 2,5-dihydroxybenzenesulfonate, potassium 2,5-dihydroxybenzenesulfonate, magnesium 2,5-dihydroxybenzenesulfonate and diethylamine 2,5-dihydroxybenzenesulfonate.

摘要翻译： 本发明描述了用于2,5-二羟基苯磺酸化合物的组合物和方法及其药学上可接受的盐。 本发明提供（a）治疗皮肤癌的方法; （b）治疗器官的癌症; （c）治疗白血病; （d）提高化疗，放射治疗和/或癌症免疫治疗的疗效; （e）治疗酒渣鼻; 和（f）通过施用包含至少一种2,5-二羟基苯磺酸化合物或其药学上可接受的盐的组合物和任选的至少一种治疗剂来治疗牛皮癣。 还公开了包含施用至少一种2,5-二羟基苯磺酸化合物或其药学上可接受的盐和至少一种治疗剂的组合物。 在本发明中，2,5-二羟基苯磺酸化合物或其药学上可接受的盐是2,5-二羟基苯磺酸，2,5-二羟基苯磺酸钙，2,5-二羟基苯磺酸钾，2,5-二羟基苯磺酸镁和二乙胺2， 5-二羟基苯磺酸盐。