发明申请
US20120149115A1 TARGETED GENOMIC REARRANGEMENTS USING SITE-SPECIFIC NUCLEASES
审中-公开
使用特定核心的目标基因组重新定位
- 专利标题： TARGETED GENOMIC REARRANGEMENTS USING SITE-SPECIFIC NUCLEASES
- 专利标题（中）： 使用特定核心的目标基因组重新定位
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申请号： US13377387申请日： 2010-06-11
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公开(公告)号： US20120149115A1公开(公告)日： 2012-06-14
- 发明人: Jin Soo Kim , Hyung Joo Lee , Eun Ji Kim
- 申请人： Jin Soo Kim , Hyung Joo Lee , Eun Ji Kim
- 申请人地址： KR Seoul KR Seoul
- 专利权人： SNU R&DB FOUNDATION,TOOLGEN INCORPORATION
- 当前专利权人： SNU R&DB FOUNDATION,TOOLGEN INCORPORATION
- 当前专利权人地址： KR Seoul KR Seoul
- 优先权： KR10-2009-0051896 20090611
- 国际申请： PCT/KR2010/003786 WO 20100611
- 主分类号： C12N15/01
- IPC分类号： C12N15/01 ; C12N5/071 ; C12N5/04 ; C12N1/16 ; C12N1/14 ; C12N1/10 ; C12N9/16 ; C12N1/20
摘要：
The present invention relates to a method for genomic DNA rearrangements, and more particularly, to a method for deletion, duplication, inversion, replacement, or rearrangement of genomic DNA using pairs of site-specific nucleases targeting two or more sites in the genome, a cell in which genomic DNA is deleted, duplicated, inverted, replaced, or rearranged by the same method, and a method for expressing the site-specific nucleases in cells. Further, the present invention relates to a method for inserting synthetic DNA molecules into the genome using site-specific nucleases targeting a pre-determined site in the genome, a cell in which DNA insertion occurs by the same method, and a method for expressing the site-specific nucleases in cells.
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