发明申请
US20120164208A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES
有权
CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
- 专利标题: CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES
- 专利标题(中): CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
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申请号: US13383684申请日: 2009-07-13
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公开(公告)号: US20120164208A1公开(公告)日: 2012-06-28
- 发明人: Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
- 申请人: Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
- 申请人地址: SG Singapore JP Aichi
- 专利权人: NANYANG TECHNOLOGICAL UNIVERSITY,MENICON CO., LTD.
- 当前专利权人: NANYANG TECHNOLOGICAL UNIVERSITY,MENICON CO., LTD.
- 当前专利权人地址: SG Singapore JP Aichi
- 国际申请: PCT/JP2009/063013 WO 20090713
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K31/722 ; A61K8/60 ; C08B37/08
摘要:
The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices for example biomedical devices such as contact lenses, bio-implants such as urinary catheters, pacemaker, heart valves, artificial heart, mammary prosthesis, intraocular lenses, wound dressings, artificial organs and delivery carriers for the bioactive reagents, total joint replacement due to their high degree of biocompatibility, antimicrobial property and good wetting characteristics. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.