公开(公告)号：US20140193476A1

公开(公告)日：2014-07-10

申请号：US14209602

申请日：2014-03-13

Applicant: Chan Bee Eng Mary ,  Poon Yin Fun ,  Mouad Lamrani ,  Shinichi Hamaguchi

Inventor： Chan Bee Eng Mary ,  Poon Yin Fun ,  Mouad Lamrani ,  Shinichi Hamaguchi

IPC: A61L27/34 ,  A61L27/20 ,  A61K8/73 ,  A61L27/54

CPC classification number: A61L27/34 ,  A61K8/042 ,  A61K8/736 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L29/043 ,  A61L29/085 ,  A61L29/145 ,  A61L31/042 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/232 ,  A61L2300/404 ,  A61Q19/00 ,  C08B37/003 ,  C08F290/10 ,  C08G81/00 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J2305/08 ,  G02B1/043 ,  C08L1/00 ,  C08F220/28 ,  C08L5/08

Abstract: The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.

Abstract translation: 本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。 水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。 为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。 水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。 本发明广泛应用于许多医疗装置。 本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

公开(公告)号：US08709470B2

公开(公告)日：2014-04-29

申请号：US13383684

申请日：2009-07-13

Applicant: Chan Bee Eng Mary ,  Poon Yin Fun ,  Mouad Lamrani ,  Shinichi Hamaguchi

Inventor： Chan Bee Eng Mary ,  Poon Yin Fun ,  Mouad Lamrani ,  Shinichi Hamaguchi

IPC: A61K9/00 ,  A61K31/722 ,  A61K8/60 ,  C08B37/08

CPC classification number: A61L27/34 ,  A61K8/042 ,  A61K8/736 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L29/043 ,  A61L29/085 ,  A61L29/145 ,  A61L31/042 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/232 ,  A61L2300/404 ,  A61Q19/00 ,  C08B37/003 ,  C08F290/10 ,  C08G81/00 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J2305/08 ,  G02B1/043 ,  C08L1/00 ,  C08F220/28 ,  C08L5/08

Abstract: The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.

Abstract translation: 本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。 水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。 为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。 水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。 本发明广泛应用于许多医疗装置。 本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

公开(公告)号：US20120164208A1

公开(公告)日：2012-06-28

申请号：US13383684

申请日：2009-07-13

Applicant: Chan Bee Eng Mary ,  Poon Yin Fun ,  Mouad Lamrani ,  Shinichi Hamaguchi

Inventor： Chan Bee Eng Mary ,  Poon Yin Fun ,  Mouad Lamrani ,  Shinichi Hamaguchi

IPC: A61K9/00 ,  A61K31/722 ,  A61K8/60 ,  C08B37/08

CPC classification number: A61L27/34 ,  A61K8/042 ,  A61K8/736 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L29/043 ,  A61L29/085 ,  A61L29/145 ,  A61L31/042 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/232 ,  A61L2300/404 ,  A61Q19/00 ,  C08B37/003 ,  C08F290/10 ,  C08G81/00 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J2305/08 ,  G02B1/043 ,  C08L1/00 ,  C08F220/28 ,  C08L5/08

Abstract: The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices for example biomedical devices such as contact lenses, bio-implants such as urinary catheters, pacemaker, heart valves, artificial heart, mammary prosthesis, intraocular lenses, wound dressings, artificial organs and delivery carriers for the bioactive reagents, total joint replacement due to their high degree of biocompatibility, antimicrobial property and good wetting characteristics. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.

Abstract translation: 本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。 水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。 为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。 水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。 本发明广泛用于诸如隐形眼镜，诸如导尿管，心脏起搏器，心脏瓣膜，人造心脏，乳房假体，人工晶状体，伤口敷料，人造器官和输送载体等生物医学装置的生物医学装置 生物活性试剂，由于其高生物相容性，抗菌性和良好的润湿特性而导致的总关节置换。 本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。