发明申请
US20120172592A1 ACID ADDITION SALTS, HYDRATES AND POLYMORPHS OF 5-(2,4-DIHYDROXY-5-ISO-PROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE AND FORMULATIONS COMPROSING THESE FORMS
有权
5-(2,4-二羟基-5-异丙基苯基)-4-(4-吗啉-4-基 - 甲苯基) - 异恶唑-3-羧酸乙酰胺和制剂的酸添加盐,水合物和多元醇 这些形式
- 专利标题: ACID ADDITION SALTS, HYDRATES AND POLYMORPHS OF 5-(2,4-DIHYDROXY-5-ISO-PROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE AND FORMULATIONS COMPROSING THESE FORMS
- 专利标题(中): 5-(2,4-二羟基-5-异丙基苯基)-4-(4-吗啉-4-基 - 甲苯基) - 异恶唑-3-羧酸乙酰胺和制剂的酸添加盐,水合物和多元醇 这些形式
-
申请号: US13415268申请日: 2012-03-08
-
公开(公告)号: US20120172592A1公开(公告)日: 2012-07-05
- 发明人: Martin James Drysdale , Brian William Dymock , Christoph Krell , Michael Mutz , Holger Petersen , Weijia Zheng
- 申请人: Martin James Drysdale , Brian William Dymock , Christoph Krell , Michael Mutz , Holger Petersen , Weijia Zheng
- 优先权: EP07103346.8 20070301
- 主分类号: C07D413/10
- IPC分类号: C07D413/10
摘要:
The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the mesylate, hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.
公开/授权文献
信息查询