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    Signal routing Optimized IC package ball/pad layout
    9.
    发明申请
    Signal routing Optimized IC package ball/pad layout 审中-公开
    信号路由优化IC封装球/焊盘布局

    公开(公告)号：US20120241208A1

    公开(公告)日：2012-09-27

    申请号：US13066656

    申请日：2011-04-20

    申请人： Holger Petersen

    发明人： Holger Petersen

    IPC分类号： H05K1/11 ,  H05K1/00

    CPC分类号： H01L23/49838 ,  H01L23/49816 ,  H01L2924/0002 ,  H01L2924/00

    摘要： This invention provides layout schemes for ball/pad regions on a printed circuit board for a small regular ball/pad region grid that provides additional space between ball/pad regions for increased wiring capability. The layout scheme is consistent with printed circuit board manufacturing requirements and minimum wiring channel requirements demanded by high density integrated circuit chips.

    摘要翻译： 本发明提供了用于小规则球/焊盘区域网格的印刷电路板上的球/焊盘区域的布局方案，其在球/焊盘区域之间提供额外的空间以增加布线能力。 布局方案与印刷电路板制造要求和高密度集成电路芯片要求的最小布线通道要求一致。

    Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms
    10.
    发明授权
    Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms 有权
    5-（2,4-二羟基-5-异丙基 - 苯基）-4-（4-吗啉-4-基甲基 - 苯基） - 异恶唑-3-甲酸乙酰胺的酸加成盐，水合物和多晶型物和包含这些形式的制剂

    公开(公告)号：US08163747B2

    公开(公告)日：2012-04-24

    申请号：US12529090

    申请日：2008-02-28

    申请人： Martin James Drysdale ,  Brian William Dymock ,  Christoph Krell ,  Michael Mutz ,  Holger Petersen ,  Weijia Zheng

    发明人： Martin James Drysdale ,  Brian William Dymock ,  Christoph Krell ,  Michael Mutz ,  Holger Petersen ,  Weijia Zheng

    IPC分类号： A61K31/535 ,  C07D413/10

    CPC分类号： C07D295/155 ,  A61K31/5377 ,  C07D261/18

    摘要： The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the mesylate, hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.

    摘要翻译： 本发明涉及5-（2,4-二羟基-5-异丙基 - 苯基）-4-（4-吗啉-4-基甲基 - 苯基） - 异恶唑-3-甲酸乙酰胺的新盐形式，特别是 甲磺酸盐，盐酸盐，酒石酸盐，磷酸盐和半富马酸盐; 到这种盐的结晶形式; 5-（2,4-二羟基-5-异丙基 - 苯基）-4-（4-吗啉-4-基甲基 - 苯基） - 异恶唑-3-甲酸乙酰胺的多晶型物; 到上述新盐形式的水合物和多晶型物; 使用上述新的盐形式来制备用于治疗由Hsp90介导的病症的药物; 涉及使用新的盐形式治疗由Hsp90介导的病症的方法; 包括这种盐形式的制剂，特别是适于静脉内施用的水溶液; 以及填充这种制剂的琥珀色玻璃容器。