发明申请
- 专利标题： Formulation of immunopotentiators
- 专利标题（中）： 免疫增强剂的配方
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申请号： US13223793申请日： 2011-09-01
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公开(公告)号： US20120177681A1公开(公告)日： 2012-07-12
- 发明人: Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
- 申请人： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
- 主分类号： A61K39/39
- IPC分类号： A61K39/39 ; C07F9/6512 ; A61K31/675 ; A61P31/12 ; C07F9/553 ; C07F9/645 ; A61P37/04 ; A61P31/04 ; C07F9/6561 ; C07F9/38
摘要：
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
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