公开(公告)号：US20190125185A1

公开(公告)日：2019-05-02

申请号：US16228979

申请日：2018-12-21

Applicant: Kirill V. Larin ,  Manmohan Singh ,  Jiasong Li ,  Zhaolong Han ,  Michael D. Twa

Inventor： Kirill V. Larin ,  Manmohan Singh ,  Jiasong Li ,  Zhaolong Han ,  Michael D. Twa

IPC: A61B3/16 ,  A61B3/10

Abstract: Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.

公开(公告)号：US20180360306A1

公开(公告)日：2018-12-20

申请号：US16112649

申请日：2018-08-25

Applicant: Manish DINKARRAO Kulkarni ,  MANMOHAN SINGH SIDHU

Inventor： Manish DINKARRAO Kulkarni ,  MANMOHAN SINGH SIDHU

IPC: A61B3/00 ,  A61B3/10 ,  A61B34/00

Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of foldable ophthalmic system. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing. Our system can be used for many modalities including optical coherence tomography.

公开(公告)号：US09393295B2

公开(公告)日：2016-07-19

申请号：US12990110

申请日：2009-04-28

Applicant: Aravind Chakrapani ,  Manmohan Singh ,  Derek O'Hagan

Inventor： Aravind Chakrapani ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/095 ,  C08J3/14 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K2039/55555 ,  A61K2039/62 ,  C08J3/14 ,  C08J2300/16 ,  C08J2367/04

Abstract: In various aspects of the present invention, nanoparticle compositions are provided which comprise (a) nanoparticles comprising at least one biodegradable polymer and (b) at least one pharmaceutical associated with the nanoparticles. In other aspects of the present invention, methods of forming nanoparticles compositions are provided, which comprise contacting a first liquid that comprises one or more biodegradable polymers dissolved in a first solvent with a second liquid that comprises a second solvent which is miscible with the first solvent while being a non-solvent for the one or more biodegradable polymers, such that nanoparticles are formed.

Abstract translation: 在本发明的各个方面，提供纳米颗粒组合物，其包含（a）包含至少一种生物可降解聚合物的纳米颗粒和（b）至少一种与纳米颗粒相关的药物。 在本发明的其他方面，提供了形成纳米颗粒组合物的方法，其包括将包含溶解在第一溶剂中的一种或多种可生物降解的聚合物的第一液体与包含与第一溶剂混溶的第二溶剂的第二液体接触 同时作为一种或多种可生物降解的聚合物的非溶剂，使得形成纳米颗粒。

公开(公告)号：US09315530B2

公开(公告)日：2016-04-19

申请号：US13820370

申请日：2011-09-01

Applicant: Manmohan Singh ,  David A. G. Skibinski ,  Tom Yao-Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Xiaoyue Zhang ,  Yefen Zou ,  Timothy Z. Hoffman ,  Jianfeng Pan ,  Kathy Yue

Inventor： Manmohan Singh ,  David A. G. Skibinski ,  Tom Yao-Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Xiaoyue Zhang ,  Yefen Zou ,  Timothy Z. Hoffman ,  Jianfeng Pan ,  Kathy Yue

IPC: A61K39/39 ,  C07F9/6561 ,  A61K31/661 ,  A61K31/6615 ,  A61K31/662 ,  A61K39/095 ,  C07D471/04 ,  C07D487/04 ,  C07F9/645 ,  C07F9/6512 ,  C07F9/6558 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K31/661 ,  A61K31/6615 ,  A61K31/662 ,  A61K39/02 ,  A61K39/05 ,  A61K39/08 ,  A61K39/092 ,  A61K39/095 ,  A61K39/13 ,  A61K39/145 ,  A61K39/292 ,  A61K2039/55505 ,  A61K2039/55511 ,  C07D471/04 ,  C07D487/04 ,  C07F9/645 ,  C07F9/6512 ,  C07F9/65583 ,  C07F9/6561 ,  C07F9/65616 ,  Y02A50/466

Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

Abstract translation: 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。

公开(公告)号：US08815253B2

公开(公告)日：2014-08-26

申请号：US12746723

申请日：2008-12-04

Applicant: Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

Inventor： Padma Malyala ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K39/02 ,  A61K49/00 ,  A61K39/00 ,  A61K31/437 ,  A61K9/16 ,  A61K39/07 ,  A61K31/4745 ,  A61K39/39

CPC classification number: A61K31/437 ,  A61K9/1647 ,  A61K31/4745 ,  A61K39/07 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  Y02A50/466

Abstract: The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) at least first and second adjuvants, wherein the first adjuvant comprises microparticles and wherein the second adjuvant comprises an imidazoquinoline compound, and (c) a pharmaceutically acceptable excipient, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.

Abstract translation: 本发明尤其提供包含（a）第一抗原，（b）至少第一和第二佐剂的免疫原性组合物，其中所述第一佐剂包含微粒，并且其中所述第二佐剂包含咪唑并喹啉化合物，和（c）药学上 可接受的赋形剂，当给予脊椎动物受试者时，该组合物引起免疫应答。 本发明还提供了产生免疫原性组合物的方法和用于使用免疫原性组合物（例如，用于治疗）的方法以及其它益处。

公开(公告)号：US20140204337A1

公开(公告)日：2014-07-24

申请号：US13744415

申请日：2013-01-18

Applicant: Manish Dinkarrao Kulkarni ,  Manmohan Singh Sidhu

Inventor： Manish Dinkarrao Kulkarni ,  Manmohan Singh Sidhu

IPC: A61B3/00 ,  A61B3/10

CPC classification number: A61B3/0083 ,  A61B3/0033 ,  A61B3/0041 ,  A61B3/102 ,  A61B34/25 ,  A61B2560/0431

Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of folding apparatus for ocular purposes for the first time. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing.

Abstract translation: 需要强大的便携式系统和用于眼科的装置。 我们建议首次使用折叠装置进行目视。 我们的系统将具有可以折叠的下颚休息（或平面休息或前额休息），使得眼睛装置可以在短型壳体中运输。

公开(公告)号：US08734832B2

公开(公告)日：2014-05-27

申请号：US13621174

申请日：2012-09-15

Applicant: Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

Inventor： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

IPC: A61F2/02 ,  A61K9/14 ,  A61K9/50

CPC classification number: A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

公开(公告)号：US20130224245A1

公开(公告)日：2013-08-29

申请号：US13700436

申请日：2011-06-01

Applicant: Sushma Kommareddy ,  Derek O'Hagan ,  Manmohan Singh ,  Amanda Bonoficio ,  Barbara Baudner

Inventor： Sushma Kommareddy ,  Derek O'Hagan ,  Manmohan Singh ,  Amanda Bonoficio ,  Barbara Baudner

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16251

Abstract: An antigen concentration procedure does not involve lyophilisation of a bulk antigen before its final formulation and/or delivery. Thus a process for preparing a vaccine comprises steps of (i) increasing the concentration of an antigen in a liquid composition including that antigen, to provide a concentrated antigen, and (ii) formulating a vaccine from the concentrated antigen. The concentrated antigen is not lyophilised between or during steps (i) and (ii). The invention is particularly useful for preparing solid vaccine forms.

Abstract translation: 抗原浓缩程序不包括在其最终制剂和/或递送之前冻干本体抗原。 因此，制备疫苗的方法包括以下步骤：（i）增加包含该抗原的液体组合物中的抗原浓度，以提供浓缩抗原，和（ii）从浓缩抗原配制疫苗。 浓缩的抗原在步骤（i）和（ii）之间或之间不被冷冻干燥。 本发明特别可用于制备固体疫苗形式。

公开(公告)号：US20130101629A1

公开(公告)日：2013-04-25

申请号：US13516227

申请日：2010-12-15

Applicant: David Skibinski ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

Inventor： David Skibinski ,  Siddhartha Jain ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/39 ,  A61K31/496 ,  A61K31/683 ,  A61K31/675 ,  A61K31/4745 ,  A61K31/5377

CPC classification number: A61K39/39 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/683 ,  A61K31/7004 ,  A61K31/717 ,  A61K39/095 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N2760/14134 ,  C12N2760/18534 ,  Y02A50/41 ,  A61K2300/00

Abstract: The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

Abstract translation: 本发明一般涉及能够刺激或调节有需要的受试者的免疫应答的小分子免疫增强剂（SMIP）的均匀悬浮液。 均匀悬浮液可以与各种抗原或佐剂组合用于疫苗疗法。

公开(公告)号：US20120156251A1

公开(公告)日：2012-06-21

申请号：US13235454

申请日：2011-09-18

Applicant: Luis BRITO ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

Inventor： Luis BRITO ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K39/385 ,  A61P31/12 ,  A61P37/00 ,  A61P35/00 ,  A61P17/00 ,  A61K9/107 ,  A61P31/04

CPC classification number: A61K39/385 ,  A61K9/107 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55566

Abstract: This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.

Abstract translation: 本发明一般涉及阳离子水包油乳液，其可用于递送带负电荷的分子，例如RNA分子。 乳剂颗粒包含油芯和阳离子脂质。 阳离子脂质可以与带负电荷的分子相互作用，从而将分子固定在乳液颗粒上。 本文所述的阳离子乳剂特别适用于将核酸分子（例如编码抗原的RNA分子）递送至细胞并配制基于核酸的疫苗。