发明申请
US20120184031A1 ANTISENSE INHIBITION VIA RNASE H-INDEPENDENT REDUCTION IN MRNA
审中-公开
通过MRNA中的RNASE H独立减少进行抗体抑制
- 专利标题： ANTISENSE INHIBITION VIA RNASE H-INDEPENDENT REDUCTION IN MRNA
- 专利标题（中）： 通过MRNA中的RNASE H独立减少进行抗体抑制
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申请号： US13351511申请日： 2012-01-17
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公开(公告)号： US20120184031A1公开(公告)日： 2012-07-19
- 发明人: Brett P. Monia , Susan M. Freier , Muthiah Manoharan , William A. Gaarde , Richard H. Griffey , Eric E.` Swayze , C. Frank Bennett
- 申请人： Brett P. Monia , Susan M. Freier , Muthiah Manoharan , William A. Gaarde , Richard H. Griffey , Eric E.` Swayze , C. Frank Bennett
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： C12N5/071
- IPC分类号： C12N5/071
摘要：
The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of an exon/intron junction on said mRNA. Preferably, said antisense compounds do not elicit RNAse H cleavage of the mRNA.
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