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    Compositions and their uses directed to hepcidin
    3.
    发明授权
    Compositions and their uses directed to hepcidin 失效
    组合物及其用于铁调素的用途

    公开(公告)号：US08076306B2

    公开(公告)日：2011-12-13

    申请号：US11734562

    申请日：2007-04-12

    申请人： Brett P. Monia ,  C. Frank Bennett ,  William A. Gaarde ,  Trisha Lockhart ,  Robert McKay

    发明人： Brett P. Monia ,  C. Frank Bennett ,  William A. Gaarde ,  Trisha Lockhart ,  Robert McKay

    IPC分类号： A61K31/70 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12N5/00

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

    摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of hepcidin in a cell, tissue or animal or preventing, ameliorating or treating anemia. Also provided are methods for prevention, amelioration or treatment of anemia, and for increasing red blood cell count in an animal. Also provided are methods for the prevention, amelioration and/or treatment of low serum iron levels, low red blood cell count and other clinical endpoints of anemia in an animal. These methods may be achieved by administration of compounds or compositions including antisense compounds targeted to a nucleic acid that expresses hepcidin polypeptide combined with an erythropoiesis stimulating agent.

    摘要翻译： 本文公开了用于调节细胞，组织或动物中铁调素表达或预防，改善或治疗贫血的化合物，组合物和方法。 还提供了用于预防，改善或治疗贫血以及用于增加动物中红细胞计数的方法。 还提供了用于预防，改善和/或治疗动物体内低血清铁水平，低红细胞计数和贫血的其它临床终点的方法。 这些方法可以通过施用化合物或组合物来实现，所述化合物或组合物包括靶向表达与促红细胞生成刺激剂组合的铁调素多肽的核酸的反义化合物。

    Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
    7.
    发明授权
    Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 有权
    反义寡核苷酸组合物和调节JNK蛋白的方法

    公开(公告)号：US06221850B1

    公开(公告)日：2001-04-24

    申请号：US09130616

    申请日：1998-08-07

    申请人： Robert McKay ,  Nicholas Dean ,  Brett P. Monia ,  Pamela Scott Nero ,  William A. Gaarde

    发明人： Robert McKay ,  Nicholas Dean ,  Brett P. Monia ,  Pamela Scott Nero ,  William A. Gaarde

    IPC分类号： A61K4800

    CPC分类号： C12N15/1137 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/3515 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. The invention is thus directed to compositions for modulating, diagnostic methods for detecting, and therapeutic methods for inhibiting, the hyperproliferation of cells and formation, development and maintenance of tumors.

    摘要翻译： 提供了通过调节编码JunN末端激酶（JNK蛋白）的基因的表达进行治疗的疾病或病症的治疗和诊断的组合物和方法。 本文提供了与编码JNK1，JNK2和JNK3的核酸以及其它JNK蛋白及其特异性同种型特异性杂交的寡核苷酸。 还提供了通过用这种寡核苷酸调节一种或多种JNK蛋白质的表达来治疗患有治疗性干预的疾病或障碍的动物的方法。 还提供了用于治疗和诊断与一种或多种JNK蛋白异常表达相关的疾病或病症的方法。 因此，本发明涉及用于调节，用于检测和用于抑制细胞过度增殖以及形成，发育和维持肿瘤的方法的治疗方法的组合物。

    Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
    10.
    发明授权
    Antisense oligonucleotide compositions and methods for the modulation of JNK proteins 失效
    反义寡核苷酸组合物和调节JNK蛋白的方法

    公开(公告)号：US06809193B2

    公开(公告)日：2004-10-26

    申请号：US09774809

    申请日：2001-01-31

    申请人： Robert McKay ,  Nicholas M. Dean ,  Brett P. Monia ,  Pamela Nero ,  William A. Gaarde

    发明人： Robert McKay ,  Nicholas M. Dean ,  Brett P. Monia ,  Pamela Nero ,  William A. Gaarde

    IPC分类号： C12N1585

    CPC分类号： C12N15/1137 ,  A61K38/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/334 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12N2310/3525

    摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.

    摘要翻译： 提供了通过调节编码JunN末端激酶（JNK蛋白）的基因的表达进行治疗的疾病或病症的治疗和诊断的组合物和方法。 本文提供了与编码JNK1，JNK2和JNK3的核酸以及其它JNK蛋白及其特异性同种型特异性杂交的寡核苷酸。 还提供了通过用这种寡核苷酸调节一种或多种JNK蛋白质的表达来治疗患有治疗性干预的疾病或障碍的动物的方法。 还提供了用于治疗和诊断与一种或多种JNK蛋白异常表达相关的疾病或病症的方法。 还提供了用于诱导凋亡和用于治疗与凋亡降低相关的疾病或病症的方法。