A method and system of optimizing a complex manufacturing process performed to achieve one or more processing objectives for the process and/or a component produced by the process. The system includes a graphical user interface, a process module, and an optimization module. The process module includes a training module, an empirical relationships database, an analytical equations database, a heuristic knowledge database, and a process models database. The graphical user interface is used to input one or more processing variables and constraints for the processing objective. The training module generates empirical relationships from the processing variable and empirical data obtained from the manufacturing process. The process module generates a process model that takes into consideration heuristic knowledge of the manufacturing process, empirical relationships, and optionally analytical equations relating to the manufacturing process. The optimization module employs the process model to optimize the manufacturing process.