ION TRAPS THAT APPLY AN INVERSE MATHIEU Q SCAN

    公开(公告)号:US20190057856A1

    公开(公告)日:2019-02-21

    申请号:US15769998

    申请日:2016-10-21

    IPC分类号: H01J49/42 H01J49/00

    摘要: The invention generally relates to ion traps and methods of use thereof. In certain embodiments, the invention provides a system that includes a mass spectrometer including an ion trap, and a central processing unit (CPU). The CPU has storage that is coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply a constant radio frequency (RF) signal to the ion trap, and apply a first alternating current (AC) signal to the ion trap the frequency of which varies as a function of time.

    Systems and methods for imaging a sample

    公开(公告)号:US11635610B2

    公开(公告)日:2023-04-25

    申请号:US17322903

    申请日:2021-05-18

    摘要: A method for imaging a sample, wherein the sample changes a polarization state of light as a function of position, wherein the method includes changing a polarization state of a purely polarized light of an incident light striking a micro-retarder array, thereby inducing a changed polarization state of the polarization state. The micro-retarder array is placed in a rear conjugate focal plane of a microscope. The method additionally includes projecting the changed polarization state of the polarization state into an object plane of the microscope containing the sample.

    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES

    公开(公告)号:US20230115304A1

    公开(公告)日:2023-04-13

    申请号:US18075578

    申请日:2022-12-06

    IPC分类号: G01N33/53

    摘要: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    NANO-COMPOSITE MICROPARTICLES OF POLYMYXIN

    公开(公告)号:US20230099696A1

    公开(公告)日:2023-03-30

    申请号:US17908492

    申请日:2021-03-05

    发明人: Qi ZHOU Chune ZHU

    IPC分类号: A61K38/12 A61K9/16 A61K9/19

    摘要: The present disclosure generally relates to a process for manufacturing a microparticle composite or a dry powder inhaler composition of polymyxin and CFTR activator or CFTR potentiator comprising the steps preparing a suspension of nanoparticles (NPs) of CFTR activator or CFTR potentiator or their combinations; mixing the suspension of NPs with a solution of polymyxin and a solution of leucine, then followed by drying to afford said micro-particle composite or dry powder inhaler composition. Pharmaceutical compositions and methods for treating a patient of cystic fibrosis (CF) and/or a lung infection are within the scope of this invention.

    MICROSTRUCTURALLY ENGINEERED PEROVSKITE GAS SENSOR

    公开(公告)号:US20230085705A1

    公开(公告)日:2023-03-23

    申请号:US17802099

    申请日:2020-10-30

    IPC分类号: G01N33/00

    摘要: A gas sensing device is provided. The gas sensing device includes a substrate, a sensing film deposited on the substrate, and a plurality of electrodes deposited on the sensing film. The sensing film comprising ReNiO3, wherein Re is a rare-earth cation wherein. At least one of the electrodes including platinum, palladium, or a combination thereof. The electrodes are spaced apart from each other for measurement of electrical resistance.